粪菌移植治疗克罗恩病的研究进展  

Research progress of fecal microbiota transplant for Crohn′s disease

作　　者：杜骏 徐治中[1] 何宗琦[1] 甄曙光[1] 文科[1] 孙薛亮[1] Du Jun;Xu Zhizhong;He Zongqi;Zhen Shuguang;Wen Ke;Sun Xueliang(Department of Colorectal Surgery,Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215000,Jiangsu Province,China)

机构地区：[1]南京中医药大学附属苏州市中医医院肛肠科,江苏苏州215000

出　　处：《中华炎性肠病杂志（中英文）》2021年第3期229-232,共4页Chinese Journal of Inflammatory Bowel Diseases

基　　金：苏州市产业技术创新专项项目(SYSD2017126)。

摘　　要：克罗恩病(CD)是临床难治性疾病,因病因不明,缺乏特效疗法。肠道菌群失调与CD密切相关。补充单一菌属治疗CD无明显疗效。粪菌移植是近年来治疗CD的新兴方法,它能增加CD患者肠道菌群多样性和丰度,有效诱导临床应答和缓解。然而,其临床确切疗效及粪菌灌注时机、剂量、频率和方式等方面存在争议,缺乏标准化方案。Crohn′s disease(CD)is a refractory disease,and is lack of a perfect therapy due to the unknown pathogenesis.Dysbiosis of intestinal microbiota is closely associated with CD.It is ineffective to treat CD with one species of probiotics.In recent years,fecal microbiota transplant is an emerging therapy for CD,which may increase the diversity and abundance of intestinal bacteria of CD patients,and induce clinical response and remission.However,there are controversies on exact efficacy,timing,dosage,and way of fecal microbiota transplant because of deficiency of standard protocol.

关 键 词：粪菌移植 克罗恩病 肠道菌群 

分 类 号：R574.62[医药卫生—消化系统]