子宫内膜癌卵巢组织冻存自体移植1例报道  

A case report of cryopreserved ovarian tissue retransplantation in endometrial cancer

作　　者：阮祥燕[1] 程姣姣 杜娟[1] 李扬璐[1] 金凤羽[1] 卢丹[1] 周蓉[2] 代荫梅[1] 周琦[1] Matthias Korell 王虎生[1] 谷牧青[1] Alfred O.Mueck Ruan Xiangyan;Cheng Jiaojiao;Du Juan;Li Yanglu;Jin Fengyu;Lu Dan;Zhou Rong;Dai Yinmei;Zhou Qi;Korell Matthias;Wang Husheng;Gu Muqing;Alfred O.Mueck(Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China;Peking University People's Hospital,Beijing 100044,China;Johanna-Etienne Hospital in Neuss,Neuss 41462,Germany;Section of Endocrinology and Menopause,Department of Women's Health,University of Tuebingen,Tuebingen 72076,Germany)

机构地区：[1]首都医科大学附属北京妇产医院,100026 [2]北京大学人民医院,100044 [3]德国诺伊斯约翰娜艾蒂安医院,41462 [4]德国图宾根大学妇产医院内分泌与绝经中心,72076

出　　处：《中华生殖与避孕杂志》2021年第7期644-649,共6页Chinese Journal of Reproduction and Contraception

基　　金：北京市自然科学基金(7202047);北京市医院管理局临床医学发展专项经费资助(XMLX201710);首都卫生发展科研专项(首发2020-2-2112,首发2016-2-2113);首都临床特色应用研究课题(Z161100000516143);北京市医院管理局“登峰”计划专项经费(DFL20181401);中国国际人才交流促进会医疗健康技术创新与人才培养专项基金(2017041900004,2018042000001,2018042000002)。

摘　　要：目的通过卵巢组织冻存及自体移植手术保护子宫内膜癌患者生育力与卵巢内分泌功能。方法对1例33岁子宫内膜癌I期患者在癌症手术过程中进行卵巢组织取材、冻存,待其癌症完全缓解后进行冻存卵巢组织自体移植手术,随访监测患者的激素水平、卵泡发育情况以及绝经相关症状。结果卵巢组织移植1个月后,改良Kupperman评分由12分降低至2分,绝经相关症状基本消失,移植第2个月卵泡刺激素降低至21.78 IU/L,雌二醇由<13.76 ng/L升高至65.55 ng/L,B超监测到有卵泡发育。移植第4个月,卵泡刺激素降至6.26 IU/L,雌二醇水平升至112.22 ng/L,移植后第9个月,雌二醇水平为118.14 ng/L,孕酮水平升高至8.96μg/L,且B超下监测到2个排卵后黄体。结论卵巢组织冻存移植2个月后卵巢功能恢复,证明卵巢组织在临床上移植成功。Objective To preserve fertility and endocrine function of an endometrial carcinoma patient by ovarian tissue cryopreservation and transplantation.Methods Part of the ovary was harvested and cryopreserved when surgery for a 33-year-old woman who was diagnosed with endometrial carcinoma.After the cancer reached remission,the patient underwent cryopreserved ovarian tissue transplantation.The endocrine hormone,follicle growth,and menopausal syndromes were detected.Results One month after the surgery of transplantation,the modified Kupperman scores decreased from 12 to 2,and the menopausal syndrome disappeared.Two months after the operation of transplantation,the concentration of follicle-stimulating hormone(FSH)decreased to 21.78 IU/L,the level of estradiol increased from 13.76 ng/L to 65.55 ng/L,and follicle growth was observed by ultrasound.Four months after the surgery of transplantation,the level of FSH decreased to 6.26 IU/L,the level of estradiol increased to 112.22 ng/L.Nine months after the operation of transplantation,the level of estradiol was 118.14 ng/L,the level of progesterone increased to 8.96μg/L,and two corpus luteum after ovulation were detected by ultrasound.Conclusion Two months after the surgery of transplantation,the ovarian function has returned to normal,which demonstrated the success of transplantation of frozen-thawed ovarian tissue.

关 键 词：卵巢组织冻存 卵巢组织移植 子宫内膜癌 卵巢排卵 卵巢功能 

分 类 号：R737.33[医药卫生—肿瘤]