无抽搐电休克治疗精神分裂症阴性症状患者的效果评价  

Effect of modified electroconvulsive therapy in patients with negative symptoms of schizophrenia

作　　者：张叶 ZHANG Ye(Psychology Department,Dalian Seventh People’s Hospital,Dalian 116023,China)

机构地区：[1]大连市第七人民医院心理科,116023

出　　处：《中国实用医药》2021年第25期55-57,共3页China Practical Medicine

摘　　要：目的对精神分裂症阴性症状患者应用无抽搐电休克治疗的临床效果进行观察及评价。方法80例精神分裂症阴性症状患者作为研究对象,随机分为对照组和观察组,每组40例。对照组应用常规药物治疗,观察组应用无抽搐电休克治疗。比较两组临床治疗效果,治疗前后阳性和阴性症状量表(PANSS)阴性症状评分,不良反应发生情况。结果观察组治疗总有效率略高于对照组,但差异无统计学意义(P>0.05)。两组治疗前PANSS阴性症状评分比较差异无统计学意义(P>0.05);观察组患者治疗4、8周的PANSS阴性症状评分分别为(36.41±3.35)、(31.19±4.54)分,均低于对照组的(41.63±4.20)、(41.07±3.94)分,差异有统计学意义(P<0.05)。观察组不良反应发生率5.00%(2/40)显著低于对照组的20.00%(8/40),差异有统计学意义(χ^(2)=4.114,P=0.043<0.05)。结论精神分裂症阴性症状患者应用无抽搐电休克治疗效果确切,安全性理想,可广泛推广并应用于临床治疗中。Objective To observe and evaluate the clinical effect of modified electroconvulsive therapy in patients with negative symptoms of schizophrenia.Methods A total of 80 patients with negative symptoms of schizophrenia as study subjects were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with conventional medicine,and the observation group was treated with modified electroconvulsive therapy.The clinical effect,negative symptom score of positive and negative symptom scale(PANSS)before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was a little higher than that of the control group,but the difference was not statistically significant(P>0.05).Before treatment,there was no statistically significant difference in PANSS negative symptom score between the two groups(P>0.05).After 4 and 8 weeks of treatment,the PANSS negative symptom scores of the observation group were(36.41±3.35)and(31.19±4.54)points,which were lower than(41.63±4.20)and(41.07±3.94)points of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 5.00%(2/40)of the observation group was significantly lower than 20.00%(8/40)of the control group,and the difference was statistically significant(χ^(2)=4.114,P=0.043<0.05).Conclusion Modified electroconvulsive therapy has certain effect on patients with negative symptoms of schizophrenia.It has ideal safety,and can be promoted and applied in clinical treatment.

关 键 词：精神分裂症 阴性症状 无抽搐电休克 治疗效果 

分 类 号：R749.3[医药卫生—神经病学与精神病学]