托拉塞米+甘露醇治疗脑出血脑水肿的效果和不良反应观察  

Effect and adverse reaction of torasemide+mannitol on cerebral edema in cerebral hemorrhage

作　　者：迟成 李希福[1] 隋怡 CHI Cheng;LI Xifu;SUI Yi(Department of Neurology,Zhuanghe Central Hospital,Dalian,Liaoning,116400,China)

机构地区：[1]辽宁省庄河市中心医院神经内科,辽宁大连116400

出　　处：《当代医学》2021年第26期13-15,共3页Contemporary Medicine

摘　　要：目的探究托拉塞米联合甘露醇治疗脑出血脑水肿的效果及对不良反应的影响。方法选取2019年12月至2020年9月本院收治的脑出血脑水肿患者64例作为研究对象,按照随机数字表法分为对照组和观察组,各32例。对照组患者采用甘露醇治疗,观察组在对照组基础上联用托拉塞米治疗,比较两组患者临床治疗效果、神经功能缺损评分、日常生活能力评分、不良反应、临床疗效及血脂水平。结果治疗前,两组患者神经功能缺损评分、日常生活能力评分比较差异无统计学意义;治疗后,观察组神经功能缺损评分低于对照组,日常生活能力评分高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义。观察组临床治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者血脂指标比较差异无统计学意义;治疗后,观察组血脂指标均低于对照组,差异有统计学意义(P<0.05)。结论托拉塞米联合甘露醇治疗脑出血脑水肿对改善神经功能缺损评分具有积极意义,可提升患者日常生活能力,用药安全性较高,可进一步提升临床治疗效果,值得临床借鉴和推广。Objective To explore the effect of torasemide combined with mannitol in the treatment of cerebral hemorrhage and cerebral edema and its influence on adverse reactions.Methods 64 patients with cerebral hemorrhage and cerebral edema in our hospital from December 2019 to September 2020 were selected as the research subjects.They were divided into control group and observation group according to random number table method,with 32 cases in each group.The control group was treated with mannitol,and the observation group was treated with torasemide on the basis of the control group.The clinical effect,neurological function defect score,daily life ability score,adverse reactions,clinical efficacy and blood lipid level were compared between the two groups.Results Before treatment,there was no significant difference in neurological deficit score and activities of daily living score between the two groups.After treatment,the neurological deficit score of the observation group was lower than that of the control group,and the ADL score of the observation group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there was no significant difference in blood lipid indexes between the two groups;after treatment,the blood lipid indexes of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05).Conclusion The combined use of torasemide and mannitol during the treatment of cerebral hemorrhage and cerebral edema has positive significance in improving the score of nerve function defect,can improve the patients'daily life ability,has higher safety of drug use,and can further improve the clinical treatment effect,which is worthy of reference and popularization.

关 键 词：托拉塞米 甘露醇 脑出血脑水肿 治疗效果 不良反应 

分 类 号：R743.34[医药卫生—神经病学与精神病学]