Human papillomavirus infection and gastric cancer risk: A metaepidemiological review  

作　　者：Jong-Myon Bae 

机构地区：[1]Department of Preventive Medicine,Jeju National University College of Medicine,Jeju-si 63243,Jeju Province,South Korea

出　　处：《World Journal of Virology》2021年第5期209-216,共8页世界病毒学杂志

摘　　要：Gastric cancer(GC)is a multifactorial disease,and several modifiable risk factors have been reported.This review summarizes and interprets two previous quantitative systematic reviews evaluating the association between human papillomavirus(HPV)infection and GC risk.The results of two systematic reviews evaluating the same hypothesis showed a statistically significant difference in summary odds ratios and their 95%confidence intervals.Thus,it is necessary to conduct a subgroup analysis of Chinese and non-Chinese studies.Additional meta-analyses that control for heterogeneity are required.Reanalysis showed that all the Chinese studies had statistical significance,whereas the nonnational studies did not.The funnel plot asymmetry and Egger's test confirmed publication bias in the Chinese studies.In addition,the proportion of HPVpositive cases in Chinese studies was 1.43 times higher than that in non-Chinese studies and 2.81 times lower in controls.Therefore,the deduced evidence is currently insufficient to conclude that HPV infection is associated with GC risk.

关 键 词：PAPILLOMAVIRUS Stomach neoplasm Case-control studies META-ANALYSIS Systematic review Risk factors 

分 类 号：R73[医药卫生—肿瘤]