Ambisense polarity of genome RNA of orthomyxoviruses and coronaviruses  

作　　者：Oleg Zhirnov 

机构地区：[1]Gamaleya Microbiology and Epidemiology Research Center,Ivanovsky Institute of Virology,Moscow 123098,Russia

出　　处：《World Journal of Virology》2021年第5期256-263,共8页世界病毒学杂志

摘　　要：Influenza viruses and coronaviruses have linear single-stranded RNA genomes with negative and positive sense polarities and genes encoded in viral genomes are expressed in these viruses as positive and negative genes,respectively.Here we consider a novel gene identified in viral genomes in opposite direction,as positive in influenza and negative in coronaviruses,suggesting an ambisense genome strategy for both virus families.Noteworthy,the identified novel genes colocolized in the same RNA regions of viral genomes,where the previously known opposite genes are encoded,a so-called ambisense stacking architecture of genes in virus genome.It seems likely,that ambisense gene stacking in influenza and coronavirus families significantly increases genetic potential and virus diversity to extend virus-host adaptation pathways in nature.These data imply that ambisense viruses may have a multivirion mechanism,like"a dark side of the Moon",allowing production of the heterogeneous population of virions expressed through positive and negative sense genome strategies.

关 键 词：Virus genome Ambisense RNA INFLUENZA CORONAVIRUS Virus diversity Virus genes 

分 类 号：R73[医药卫生—肿瘤]