儿童非霍奇金淋巴瘤长期生存者生活质量及相关人口学因素研究  

Quality of life and related demographic factors in long-term survivors of childhood non-Hodgkin's lymphoma

作　　者：胡洋 伍柳红 管惠捷 吴素云 刘龙珍 蔡瑞卿[1] 许艳洁 张翼鷟 孙晓非[1] 朱佳 HU Yang;WU Liu-Hong;GUAN Hui-Jie;WU Su-Yun;LIU Long-Zhen;CAI Rui-Qing;XU Yan-Jie;ZHANG Yi-Zhuo;SUN Xiao-Fei;ZHU Jia(Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China)

机构地区：[1]中山大学肿瘤防治中心/华南肿瘤学国家重点实验室/肿瘤医学协同创新中心,广东广州510060

出　　处：《中国当代儿科杂志》2021年第9期882-888,共7页Chinese Journal of Contemporary Pediatrics

摘　　要：目的评估儿童非霍奇金淋巴瘤(non‐Hodgkin lymphoma,NHL)长期生存者的生活质量,探讨其相关人口学因素。方法回顾性收集初诊年龄<18岁,在中山大学肿瘤防治中心接受NHL诊治,至随访时长期生存,目前年龄≥18岁者的临床和人口学特征资料。使用健康调查简表(The MedicalOutcomesStudy 36-Item Short Form HealthSurvey,SF-36)和欧洲癌症研究与治疗组织生活质量问卷(Quality ofLifeQuestionnaire-Core 30,QLQC30)中文版的症状子量表进行调查。以美国普通成年人口(美国常模)及中国香港普通成年人口(中国香港常模)为对照,将NHL长期生存者SF-36量表各维度得分与之进行比较分析;分析NHL长期生存者SF-36量表各维度得分与其人口学特征的相关性。根据QLQ-C30量表得分对NHL长期生存者目前的症状进行评价。结果随访资料完整的23例NHL患者纳入研究,病理分型包括弥漫大B细胞淋巴瘤10例,伯基特淋巴瘤4例,T细胞淋巴母细胞瘤5例,B细胞淋巴母细胞瘤3例,自然杀伤/T细胞淋巴瘤1例,均接受过含蒽环类和烷化类药物化疗方案的治疗。目前中位年龄为26.2(16.9~55.8)岁,初诊中位年龄为10.4(2.4~17.6)岁,其中,6例已婚已育,2例患有其他慢性疾病。长期生存者的总体健康状况与美国常模相比,生理职能、一般健康状况、情感职能和精神健康评分差异无统计学意义(P>0.05),其他维度评分优于常模(P<0.05);与中国香港常模相比得出的结果类似。初诊年龄与SF-36量表社会功能、生理职能、一般健康状况呈负相关(P<0.05);目前年龄与生理机能呈正相关,与一般健康状况呈负相关(P<0.05);患者的城乡分布与一般健康状况呈负相关(P<0.05)。此外,儿童NHL长期生存者QLQ-C30症状得分较低,症状多集中在轻度,中重度症状较少。结论儿童NHL长期生存者的总体健康状况较好,与一般人群无明显差异;患者的初诊年龄是影响生活质量的主要人口学因素。Objective To evaluate the quality of life and related demographic factors in long-term survivors of childhood non-Hodgkin's lymphoma(NHL).Methods A retrospective analysis was performed on the medical and demographic data of the NHL patients who received treatment in the Sun Yat-sen University Cancer Center and achieved long-term survival at follow-up,with an age of<18 years at initial diagnosis and a present age of≥18 years.A questionnaire survey was performed using 36-Item Short-Form Health Survey(SF-36)and the symptom subscale of the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30(QLQ-C30).The health status of long-term survivors of NHL was evaluated by comparing the scores of various dimensions of the SF-36 scale of general adult population in the United States(American norm)and those of the SF-36 scale of general adult population in Hong Kong,China(Hong Kong norm).The correlation between the score of each dimension of the scale and demographic characteristics was evaluated.The symptoms of long-term NHL survivors were evaluated according to the score of QLQ-C30 scale.Results A total of 23 patients with NHL with complete follow-up data were enrolled.The pathological types included diffuse large B-cell lymphoma in 10 patients,Burkitt lymphoma in 4 patients,T-cell lymphoblastoma in 5 patients,B-cell lymphoblastoma in 3 patients,and natural killer/T cell lymphoma in 1 patient.All patients received the chemotherapy regimen containing anthracyclines and alkylating agents.The median present age was 26.2 years(range:16.9-55.8 years),and the median age at initial diagnosis was 10.4 years(range:2.4-17.6 years).Among the 23 patients,6 were married and had children and 2 had chronic diseases.There was no significant difference between the long-term survivors and the US norm in role physical,general health,role-emotional,and mental health(P>0.05),while the long-term survivors had significantly better scores of the other dimensions than the US norm(P<

关 键 词：非霍奇金淋巴瘤 生活质量 人口学因素 初诊年龄 儿童 

分 类 号：R733.1[医药卫生—肿瘤]