新辅助化疗联合改良根治术治疗对乳腺癌患者预后及金属蛋白酶组织抑制剂-1/2、基质金属蛋白酶-2/9的影响  

The effect of neoadjuvant chemotherapy combined with modified radical mastectomy on the prognosis and serum levels of TIMP-1/2 and MMP-2/9 in patients with breast cancer

作　　者：薛兰辉 胡海峰[1] 王志尚 姚得顺 XUE Lan-hui;HU Hai-feng;WANG Zhi-shang;YAO De-shun(The First Ward of Oncology Department,Affiliated Hospital of Yan'an University,Yan'an 716000,China)

机构地区：[1]延安大学附属医院肿瘤科一病区,陕西延安716000

出　　处：《实用医院临床杂志》2021年第5期93-96,共4页Practical Journal of Clinical Medicine

基　　金：河北省2020年度医学科学研究课题计划(编号20200166)。

摘　　要：目的研究新辅助化疗联合改良根治术治疗方案对乳腺癌患者预后以及金属蛋白酶组织抑制剂-1/2(TIMP-1/2)、基质金属蛋白酶-2/9(MMP-2/9)指标的影响。方法选取本院368例乳腺癌患者,采用随机数字表法分为试验组及对照组各184例,两组患者均采用改良根治术进行乳腺癌治疗,试验组在根治术基础上联合新辅助化疗方案进行治疗。观察两组患者预后情况以及血清TIMP-1/2、MMP-2/9水平变化。结果治疗后两组患者血清TIMP-1/2、MMP-2/9水平均明显下降,且试验组TIMP-1/2、MMP-2/9下降幅度显著低于对照组,差异有统计学意义(P<0.05);试验组患者总有效率85.87%优于对照组的57.6%,生活质量评估量表各项评分满意度高于对照组患者,差异均有统计学意义(P<0.05)。结论采用新辅助化疗联合改良根治术对乳腺癌患者进行治疗,不仅可以提高患者治疗效果,还可以明显改善患者的术后生活质量。Objective To investigate the effect of neoadjuvant chemotherapy combined with modified radical mastectomy on the prognosis of breast cancer patients and serum levels of TIMP-1/2 and MMP-2/9.Methods A total of 368 breast cancer patients in our hospital were randomly divided into experimental group and control group,184 in each group.Both groups of patients were treated with modified radical mastectomy.The experimental group was treated with neoadjuvant chemotherapy on the basis of radical mastectomy.The prognosis and the levels of serum TIMP-1/2 and MMP-2/9 were observed.Results After treatment,the levels of serum TIMP-1/2 and MMP-2/9 were decreased significantly in both groups,but the decrease of the levels in the experimental group was significantly lower than that in the control group(P<0.05).The total effective rate of the experimental group was 85.87%that was better than 57.6%of the control group.The satisfaction with various scores of the quality of life assessment scale of the experimental group was higher than that of the control group(P<0.05).Conclusion Neoadjuvant chemotherapy combined with modified radical mastectomy can not only improve the treatment effect,but also significantly improve the postoperative quality of life of the patients.

关 键 词：新辅助化疗 改良根治术 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]