Determination of Fusidic Acid Susceptibility of Multidrug-resistant Gonococcal Isolates from China  

作　　者：Fan Yang Stijn van der Veen 

机构地区：[1]Department of Microbiology and Parasitology,School of Medicine,Zhejiang University,Hangzhou,China [2]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China [3]Department of Dermatology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,China

出　　处：《Infectious Microbes & Diseases》2019年第2期70-74,共5页感染微生物与疾病（英文）

基　　金：This work was supported by the Zhejiang Provincial Natural Science Foundation of China(grant number LR16H190001).

摘　　要：The currently recommended gonococcal therapies are rapidly losing efficacy and;therefore,novel options for treatment are urgently required to ensure future treatment remains available.Here we investigated the susceptibility of 379 contemporary clinical Neisseria gonorrhoeae isolates from China for susceptibility to fusidic acid.These isolates include numerous multidrug-resistant strains with resistance or reduced susceptibility against ceftriaxone and/or azithromycin,antimicrobials that are currently recommended as a first-line dual therapy.Although official susceptibility breakpoints have not been established,all gonococcal isolates appeared to be susceptible to fusidic acid,with the majority of isolates displaying a minimal inhibitory concentration(MIC)of 0.25 or 0.5mg/L.Overall,the MIC90 was 0.5mg/L,with a MIC range of 0.08-2mg/L.Importantly,no correlation between fusidic acid susceptibility and susceptibility to ceftriaxone or azithromycin was observed.Further analysis of gonococcal survival curves indicated that fusidic acid was only mildly bactericidal at the highest tested concentrations(4
MIC).In conclusion,fusidic acid displayed consistent antimicrobial activity against N.gonorrhoeae and,given the absence of cross-resistance with ceftriaxone and azithromycin,might be interesting for further evaluation of single or dual antimicrobial therapies in combination with ceftriaxone or azithromycin.

关 键 词：fusidic acid MULTIDRUG-RESISTANCE Neisseria gonorrhoeae 

分 类 号：R28[医药卫生—中药学]