Orosomucoid-like protein 3,rhinovirus and asthma  

作　　者：You-Ming Zhang 

机构地区：[1]Section of Genomic and Environmental Medicine,National Heart and Lung Institute,Molecular Genetics Group,Division of Respiratory Sciences,Imperial College London,London SW36LY,United Kingdom

出　　处：《World Journal of Critical Care Medicine》2021年第5期170-182,共13页世界重症医学杂志

摘　　要：The genetic variants of orosomucoid-like protein 3(ORMDL3)gene are associated with highly significant increases in the number of human rhinovirus(HRV)-induced wheezing episodes in children.Recent investigations have been focused on the mechanisms of ORMDL3 in rhinovirus infection for asthma and asthma exacerbations.ORMDL3 not only regulates major human rhinovirus receptor intercellular adhesion molecule 1 expression,but also plays pivotal roles in viral infection through metabolisms of ceramide and sphingosine-1-phosphate,endoplasmic reticulum(ER)stress,ER-Golgi interface and glycolysis.Research on the roles of ORMDL3 in HRV infection will lead us to identify new biomarkers and novel therapeutic targets in childhood asthma and viral induced asthma exacerbations.

关 键 词：ASTHMA Intercellular adhesion molecule 1 Orosomucoid-like protein 3 Rhinovirus infection SPHINGOLIPIDS 

分 类 号：R562.25[医药卫生—呼吸系统]