Nascent RNA m^(6)A modification at the heart of the gene-retrotransposon conflict  

作　　者：Victor Billon Gael Cristofari 

机构地区：[1]Universite Cote d'Azur,Inserm,CNRS,IRCAN,Nice,France

出　　处：《Cell Research》2021年第8期829-831,共3页细胞研究（英文版）

摘　　要：Retrotransposons are highly abundant mobile genetic elements in mammalian genomes and can interfere with many genomic processes,particularly the transcription of genes.A study by Xiong et al.reveals that segments of nascent RNAs containing retrotransposons are enriched in N^(6)-methyladenosine and act as transcriptional roadblocks for elongating RNA polymerase II,but that cellular proteins capable of binding to these RNAs,SAFB/SAFB2,can mitigate this effect.

关 键 词：RETROTRANSPOSONS gene-retrotransposon 

分 类 号：Q78[生物学—分子生物学]