Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain  

作　　者：Kaikai Wang Sashuang Wang Yan Chen Dan Wu Xinyu Hu Yingjin Lu Liping Wang Lan Bao Changlin Li Xu Zhang 

机构地区：[1]Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China [2]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]Research Unit of Pain,Chinese Academy of Medical Sciences,Institute of Brain-Intelligence Science and Technology,Zhangjiang Lab,Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 200031,China [5]Shanghai Clinical Research Center,Chinese Academy of Sciences,Xuhui Central Hospital,Shanghai 200031,China [6]Shenzhen Key Lab of Neuropsychiatric Modulation,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [7]State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science,Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《Cell Research》2021年第8期904-918,共15页细胞研究（英文版）

基　　金：supported by National Natural Science Foundation of China(31671094,31630033,and 31600853);Chinese Academy of Sciences(QYZDY5SW-SMC007);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39050100);the International Partnership Program of Chinese Academy of Sciences(172644KYS820170004);Science and Technology Commission of Shanghai Municipality(18JC1420301);Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences(2019-I2M-5-082).

摘　　要：Peripheral nerve injury could lead to chronic neuropathic pain.Understanding transcriptional changes induced by nerve injury could provide fundamental insights into the complex pathogenesis of neuropathic pain.Gene expression profiles of dorsal root ganglia(DRG)in neuropathic pain condition have been studied.However,little is known about transcriptomic changes in individual DRG neurons after peripheral nerve injury.

关 键 词：PAIN PATHOGENESIS INSIGHT 

分 类 号：Q42[生物学—神经生物学]