HOTAIR表达水平与结直肠癌患者预后关系的分析  

Prognostic role of HOTAIR in colorectal cancer:A meta-analysis

作　　者：王柏清[1] 王珏磊[1] 张宝芹[1] 李甜甜[1] 王超 孙光斌 Bai-Qing Wang;Jue-Lei Wang;Bao-Qin Zhang;Tian-Tian Li;Chao Wang;Guang-Bin Sun(The Fifth Central Hospital of Tianjin,Tianjin 300450,China)

机构地区：[1]天津市第五中心医院消化科,天津市300450

出　　处：《世界华人消化杂志》2021年第17期984-989,共6页World Chinese Journal of Digestology

摘　　要：背景结直肠癌是最常见的恶性肿瘤之一,能够找到早期发现和评估肿瘤预后的生物标志物十分必要.近年来研究发现,HOX转录反义RNA(HOX transcript antisense RNA,HOTAIR)在包括结直肠癌的各种癌症中表达升高,但由于各个研究样本量较小,说服力不强.目的采用Meta分析的方法对HOTAIR表达水平与结直肠癌患者预后的关系进行探讨.方法通过对Pub Med、Medline、CNKI、CBM和Cochrane图书馆的搜索,检索2020-12发表的有关HOTAIR表达水平与结直肠癌患者预后关系的文献.两名评价员独立进行纳入文献的质量评价和数据提取,计算总生存期(overall survival,OS)的危险比(hazard ratio,HR)以及淋巴结转移(lymph node metastasis,LNM)和远处转移(distant metastasis,DM)的优势比(odds ratios,OR),以评估关联强度.结果符合纳入标准的7篇文献被纳入.其中6篇比较了HOTAIR表达水平与OS的相关性,结果显示两组间差异有统计学意义(OR=2.36,95%CI:1.74-3.19,P<0.05).5篇比较了HOTAIR表达水平与LNM的相关性,两组间差异有统计学意义(OR=4.07,95%CI:1.38-12.0,P<0.05).4篇比较了HOTAIR表达水平与DM的相关性,两组间差异有统计学意义(OR=4.32,95%CI:1.60-11.62,P<0.05).结论结直肠癌组织中HOTAIR的高表达与OS降低和LNM、DM有显著的相关性,提示HOTAIR有可能作为一种判断肿瘤预后的新型生物标志物,对结直肠癌患者的预后监测具有一定的意义.BACKGROUND Colorectal cancer is one of the most common malignant tumors.It is essential to find biomarkers for the early detection and evaluation of tumor prognosis.In recent years,studies have revealed that the expression of Hox transcription antisense RNA(HOTAIR)increases in various cancers,including colorectal cancer.However,due to the small sample size of each study,the persuasiveness is not strong.AIM To perform a meta-analysis to explore the relationship between the expression of HOTAIR and the prognosis of colorectal cancer.METHODS Pub Med,MEDLINE,CNKI,CBM,and The Cochrane Library were searched for articles published before December 2020 on the relationship between HOTAIR expression and the prognosis of patients with colorectal cancer.Two reviewers independently evaluated the quality of the included articles and extracted the data.The risk ratio(HR)of overall survival(OS)and the odds ratio of lymph node metastasis(LNM)and distant metastasis(DM)were calculated to evaluate the association strength.RESULTS Seven articles that met the inclusion criteria were included.Six of them compared the correlation between HOTAIR expression level and OS,and the results suggested that there existed a significant correlation between them(OR=2.36,95%CI:1.74-3.19,P<0.05).The correlation between HOTAIR expression level and LNM was compared in five articles,with a statistically significant correlation observed(OR=4.07,95%CI:1.38-12.0,P<0.05).Four articles compared the correlation between HOTAIR expression level and DM,and there was a statistically significant correlation between them(OR=4.32,95%CI:1.60-11.62,P<0.05).CONCLUSION The high expression of HOTAIR in colorectal cancer is significantly correlated with decreased OS,LNM,and DM,which indicates that HOTAIR may be a new biomarker for evaluating the prognosis of colorectal cancer.

关 键 词：HOX转录反义RNA HOTAIR 结直肠癌 Meta分析 

分 类 号：R735.34[医药卫生—肿瘤]