血清尿酸评估HBV相关性慢加急性肝衰竭预后的临床价值  

Clinical value of serum uric acid in evaluating the prognosis of HBV related acute on chronic liver failure

作　　者：杨凯 刘治华 陈谨[1] 宇芙蓉[1] 刘萍[1] 孟德娣 金蕾[2] 张发苏 YANG Kai;LIU Zhi-hua;CHEN Jin(Anhui Medical College,Hefei 230601,Anhui)

机构地区：[1]安徽医学高等专科学校,安徽合肥230601 [2]安徽医科大学第二附属医院,安徽合肥230601

出　　处：《安徽医专学报》2021年第4期88-90,共3页Journal of Anhui Medical College

基　　金：安徽省教育厅省级教学质量工程(编号:2020jyxm0950)。

摘　　要：目的:探讨乙型肝炎病毒(HBV)相关性慢加急性肝衰竭(HBV-ACLF)患者血清尿酸含量与患者临床预后关系。方法:104例HBV-ACLF患者和112例慢性HBV感染患者为研究对象。比较HBV-ACLF患者和慢性HBV感染患者血清UA含量差异,并分析HBV-ACLF患者UA与TBIL及INR相关性。受试者工作特征曲线评估血清UA预测HBV-ACLF患者住院30天死亡的临床价值。结果:与慢性HBV感染患者相比较,HBV-ACLF患者血清UA含量显著降低(P<0.001)且与TBIL和INR呈显著负相关。与住院30天未死亡患者相比,死亡患者血清UA显著下降(P<0.001)。血清UA预测HBV-ACLF患者住院30天死亡的曲线下面积为0.879。结论:血清UA具有潜在评估HBV-ACLF患者短期预后的临床价值。Objective:To investigate the relationship between serum uric acid level and clinical prognosis in patients with HBV-ACLF.Methods:104 patients with HBV-ACLF and 112 patients with chronic HBV infection were studied.The difference of serum uric acid(UA)concentration in HBV-ACLF patients and chronic HBV infection patients were compared,and relationship between UA,TBIL and INR in HBV-ACLF patients were analysed.The clinical value of serum UA in predicting 30-day hospital death in HBV-ACLF patients was analyzed using receiver operating characteristic curves(ROC).Results:The serum UA level was significantly lower in the HBV-ACLF patients when compared with the chronic HBV infection patients(P<0.001).The significantly negative correlations were found between UA and TBIL and INR(P<0.001)in patients with HBV-ACLF.HBV-ACLF Patients who died within the first 30 days of hospitalization have lower value of serum UA than those who survived(P<0.001).ROC curve analysis showed that the area under the curve of serum UA predicting 30-day death in HBV-ACLF patientswas 0.879.Conclusion:Serum UA has potential clinical value in evaluating the short-term prognosis in HBV-ACLF patients.

关 键 词：乙型肝炎病毒 慢加急性肝衰竭 尿酸 预后 

分 类 号：R575.3[医药卫生—消化系统]