Clinical effectiveness of adding probiotics to a low FODMAP diet:Randomized double-blind placebo-controlled study  

作　　者：Beril Turan Göksel Bengi Ruksan Cehreli Hale Akpınar Müjde Soytürk 

机构地区：[1]Department of Internal Medicine,Dokuz Eylül University,Izmir 35000,Turkey [2]Department of Gastroenterology,Dokuz Eylul University Izmir,Izmir 35000,Turkey [3]Department of Preventive Oncology,Dokuz Eylül University,Institute of Oncology,İzmir 35000,Turkey

出　　处：《World Journal of Clinical Cases》2021年第25期7417-7432,共16页世界临床病例杂志

摘　　要：BACKGROUND There are various studies showing the relationship between irritable bowel syndrome(IBS)and diet,and some dietary adjustments are recommended to reduce symptoms.In recent years,there is a growing number of studies that show a 4-8 wk low fermentable oligo,di-and mono-saccharides and polyols(FODMAP)diet has a 50%-80%significant effect on symptoms in IBS patients.There is strong evidence suggesting that changes in fecal microbiota have an impact on IBS pathogenesis.Based on this argument,probiotics have been used in IBS treatment for a long time.As is seen,the FODMAP diet and probiotics are used separately in IBS treatment.AIM To evaluate the effectiveness of adding probiotics to a low FODMAP diet to control the symptoms in patients with IBS.METHODS The patients who were admitted to the Gastroenterology Clinic of Dokuz Eylul University Hospital and diagnosed with IBS according to Rome IV criteria were enrolled into the study.They were randomized into 2 groups each of which consisted of 50 patients.All patients were referred to a dietitian to receive dietary recommendations for the low FODMAP diet with a daily intake of 9 g.The patients were asked to keep a diary of foods and beverages they consumed.The patients in Group 1 were given supplementary food containing probiotics(2 g)once a day in addition to their low FODMAP diet,while the patients in Group 2 were given a placebo once a day in addition to their low FODMAP diet.Visual analogue scale(VAS),the Bristol Stool Scale and IBS Symptom Severity Scale(IBSSSS)scores were evaluated before and after the 21 d treatment.RESULTS The rate of adherence of 85 patients,who completed the study,to the FODMAP restricted diet was 92%,being 90%in Group 1 and 94%in Group 2.The mean scores of VAS and IBS-SSS of the patients in Group 1 before treatment were 4.6±2.7 and 310.0±78.4,respectively,and these scores decreased to 2.0±1.9 and 172.0±93.0 after treatment(both P<0.001).The mean VAS and IBS-SSS scores of the patients in Group 2 before treatment were 4.7±2.7 and 31

关 键 词：Irritable bowel syndrome PROBIOTICS Low Fermentable Oligo Di-and Mono-Saccharides and Polyols diet Visual Analogue Scale the Bristol Stool Scale Irritable Bowel Syndrome Symptom Severity Scale 

分 类 号：R574.4[医药卫生—消化系统]