基于高分辨率CT图像特征及纹理参数分析肺腺癌TRIM28、LAPTM4B表达的危险因素  

Analysis of risk factors for the expression of TRIM28 and LAPTM4B in lung adenocarcinoma based on high-resolution CT image features and texture parameters

作　　者：王慧[1] 闫圆圆[2] 巩贯忠[3] 李娜[1] WANG Hui;YAN Yuan-yuan;GONG Guan-zhong(Department of Occupational Diseases,the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001,China)

机构地区：[1]山东中医药大学第二附属医院职业病科,济南250001 [2]山东省肿瘤防治研究院影像科,济南250117 [3]山东省肿瘤防治研究院放射物理技术科,济南250117

出　　处：《放射学实践》2021年第9期1101-1105,共5页Radiologic Practice

摘　　要：目的:探讨肺腺癌高分辨率CT图像特征及纹理参数与三结构域蛋白28(TRIM28)、溶酶体相关4次跨膜蛋白B(LAPTM4B)表达的相关性。方法:纳入行手术治疗的182例肺腺癌患者作为研究对象,术中取患者的肺腺癌组织和癌旁正常组织。患者行胸部CT检查,记录肿瘤大小、肿瘤边界、有无分叶征、毛刺征、血管集束征、胸膜牵拉征、空气支气管征及空泡征和CT纹理参数,包括偏度、平均值、熵值、能量、峰度、均质性和自相关。肺腺癌组织和癌旁正常组织中的TRIM28和LAPTM4B表达水平应用免疫组织化学法进行检测。结果:TRIM28高表达者中出现肿瘤边界不规整、分叶征、毛刺征和胸膜牵拉征的比例(分别为67.0%、62.5%、70.5%、69.3%)显著高于低表达者(分别为50.0%、44.7%、53.2%、44.7%),差异均有统计学意义(P值均<0.05);TRIM28高表达者CT纹理参数中的峰度(17.52±2.56)显著高于低表达者(8.76±1.74),而均质性(0.14±0.02)显著低于低表达者(0.18±0.03),差异均有统计学意义(P值均<0.05)。LAPTM4B高表达者中出现分叶征、毛刺征、血管集束征和空气支气管征的比例(分别为66.7%、72.2%、64.4%、63.3%)显著高于低表达者(分别为40.2%、51.1%、45.7%、44.6%),差异均有统计学意义(P值均<0.05);LAPTM4B高表达者CT纹理参数中的的峰度(18.48±2.77)和熵值(3.20±0.37)与低表达者(分别为8.36±1.88、2.61±0.30)相比显著升高,差异均有统计学意义(P值均<0.05)。对单因素分析中有统计学意义的因素进行多因素Logistic回归分析,结果显示肿块边界不光整、分叶征、峰度升高及均质性降低是TRIM28高表达的独立危险因素(P值均<0.05),分叶征、血管集束征、峰度和熵值升高是LAPTM4B高表达的独立危险因素(P值均<0.05)。结论:高分辨率CT图像特征及纹理参数与肺腺癌TRIM28和LAPTM4B蛋白表达水平有关,有助于预测疾病预后及制定临床治疗方案。Objective:To explore the correlation between the high-resolution CT image features and texture parameters and the expression of tri-domain protein 28(TRIM28)and lysosomal associated four transmembrane protein B(LAPTM4B)in lung adenocarcinoma.Methods:A total of 182 patients with lung adenocarcinoma who received surgical treatment were included in this study,and lung adenocarcinoma tissues and paracancerous normal tissues of the patients were collected intraoperatively.The patients underwent chest CT examination,and tumor size,tumor boundary,lobulation sign,spiculation sign,vessel convergence sign,pleural indentation sign,air bronchogram sign,vacuole sign and CT texture parameters,including bias,mean value,entropy,energy,kurtosis,homogeneity and autocorrelation,were recorded.The expression levels of TRIM28 and LAPTM4B in lung adenocarcinoma tissues and paracancerous normal tissues were determined by immunohistochemistry.Results:The proportion of irregular tumor boundary,lobulation sign,speculation sign and pleural indentation sign in patients with high expression of TRIM28(67.0%,62.5%,70.5%and 69.3%,respectively)was significantly higher than that in patients with low expression of TRIM28(50.0%,44.7%,53.2%and 44.7%,respectively)(all P<0.05).The kurtosis of CT texture parameters in the high expression TRIM28 group(17.52±2.56)was significantly higher than that in the low expression TRIM28 group(8.76±1.74),while the homogeneity of the high expression TRIM28 group(0.14±0.02)was significantly lower than that in the low expression TRIM28 group(0.18±0.03)(all P<0.05).The proportion of lobulation sign,spiculation sign,vessel convergence sign and air bronchogram sign in high LAPTM4B expression group(66.7%,72.2%,64.4%,and 63.3%,respectively)was significantly higher than that in low LAPTM4B expression group(40.2%,51.1%,45.7%,and 44.6%,respectively)(all P<0.05).The kurtosis(18.48±2.77)and entropy(3.20±0.37)in CT texture parameters of LAPTM4B with high expression were significantly higher than those of LAPTM4B with low exp

关 键 词：肺腺癌 体层摄影术 X线计算机 纹理分析 TRIM28 LAPTM4B 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]