时辰化疗联合调强放疗在局部进展期鼻咽癌患者治疗中的应用  

Application of Chrono-Chemotherapy Combined with Intensity-Modulated Radiotherapy in Treating patients with Locally Advanced Nasopharyngeal Carcinoma

作　　者：谢强[1] XIE Qiang(Department of Imaging,Henan Luohe Central Hospital,Luohe 462000,Henan Province,China)

机构地区：[1]河南省漯河市中心医院影像科,河南漯河462000

出　　处：《罕少疾病杂志》2021年第5期8-9,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨时辰化疗联合调强放疗在局部进展期鼻咽癌患者治疗中的应用。方法选取我院收治的88例局部进展期鼻咽癌患者作为研究对象,随机分为观察组和对照组,每组44例。两组患者均给予调强放疗,观察组患者在其基础上加用时辰化疗模式给药,对照组患者采用常规化疗模式给药。观察两组患者同步放化疗2个周期后临床疗效及治疗期间不良反应发生情况差异。结果同步放化疗2个周期后,两组患者治疗RR差异比较无统计学意义(P>0.05)。治疗期间,两组患者中性粒细胞减少、口腔黏膜炎、WBC减少及呕吐发生率差异均具有统计学意义,观察组患者不良反应程度明显较对照组轻(均P<0.05)。结论时辰化疗联合调强放疗可有效保障临床疗效,使不良反应严重程度得以降低,具有较高临床应用价值。Objective To explore the application of chrono-chemotherapy combined with intensity-modulated radiotherapy in the treatment of patients with locally advanced nasopharyngeal carcinoma.Methods 88 patients with locally advanced nasopharyngeal carcinoma who were treated in our hospital were selected as the research subjects,and they were randomly classified as the observation group and the control group,with 44 cases in each group.Both groups were given intensity-modulated radiotherapy,and the patients in observation group were additionally administered with chrono-chemotherapy model on this basis,and the patients in control group were administered with conventional chemotherapy model.The differences in clinical efficacy after 2 cycles of concurrent radiochemotherapy and occurrence of adverse reactions during treatment were observed in the two groups.Results After 2 cycles of concurrent radiochemotherapy,there was no statistical significance in the comparison of treatment RR in two groups(P>0.05).During treatment,there were statistically significant differences in the incidence rates of neutropenia,oral mucositis,leukopenia and vomiting between the two groups,and the degree of adverse reactions was obviously milder in observation group compared to control group(all P<0.05).Conclusion Chrono-chemotherapy combined with intensity-modulated radiotherapy can not only effectively guarantee the clinical efficacy,but also relieve the severity of adverse reactions,and has high clinical application value.

关 键 词：局部进展期鼻咽癌 时辰化疗 调强放疗 

分 类 号：R739.62[医药卫生—肿瘤]