Allylation and alkylation of oxindoleketimines via imine umpolung strategy  

作　　者：Mei-Hua Shen Chen Li Qing-Song Xu Bin Guo Rui Wang Xiaoqian Liu Hua-Dong Xu Defeng Xu 

机构地区：[1]Jiangsu Key Laboratory of Advanced Catalytic Materials&Technology,School of Pharmacy,Changzhou University,Changzhou 213164,China

出　　处：《Chinese Chemical Letters》2021年第7期2313-2316,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.21672027)for financial support;supported by High-Level Entrepreneurial Talent Team of Jiangsu Province(No.2017-37)。

摘　　要：When treated with an alkoxide base like t-BuOK in aprotic solvent,N-di phenyl methyl imino oxindoles,made conveniently through condensation of corresponding isatins with N-di phenyl methyl amine,are deprotonated to form azaallyl anions.Allylation and alkylation of this type of intermediates proceed smoothly with diverse C-electrophiles.Acidic work up finishes 3-amino-3-allyl/alkyl oxindoles.The overall transformation equals to an umpolung process at the C3 of isatins.

关 键 词：ALLYLATION ALKYLATION Azaallylaion UMPOLUNG Oxindleketamine Spiro oxindole 

分 类 号：O621.25[理学—有机化学]