Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques  

作　　者：Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin 

机构地区：[1]Beijing Advanced Innovation Center for Tree Breeding by Molecular Design,Beijing Forestry University,Beijing 100083,China [2]College of Biological Sciences and Biotechnology,Beijing Forestry University,Beijing 100083,China [3]School of Life Sciences,Centre for Cell&Developmental Biology and State Key Laboratory of Agrobiotechnology,The Chinese University of Hong Kong,Hong Kong 999077,China [4]State Key Laboratory of Subtropical Silviculture,Zhejiang A&F University,Hangzhou 311300,China [5]Key Laboratory of Cell Proliferation and Regulation Biology,Ministry of Education,College of Life Science,Beijing Normal University,Beijing 100875,China [6]Key Laboratory of Plant Stress Biology,School of Life Sciences,Henan University,Kaifeng 457004,China [7]College of Biological Sciences,China Agricultural University,Beijing 100193,China [8]State Key Laboratory of Plant Physiology and Biochemistry,Department of Plant Sciences,College of Biological Sciences,China Agricultural University,Beijing 100193,China [9]State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,and National Center for Plant Gene Research,Beijing 100101,China [10]Key Laboratory of Ministry of Education for Cell Proliferation and Differentiation,College of Life Sciences,Peking University,Beijing 100871,China

出　　处：《Science China(Life Sciences)》2021年第9期1392-1422,共31页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(31530084,32000558,32000483,and31800504);the Programme of Introducing Talents of Discipline to Universities(111 project,B13007);the China Postdoctoral Science Foundation Grant(2019M660494)。

摘　　要：In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field.

关 键 词：multiscale network connectivity CYTOSKELETON membrane contact site organelle interaction MULTICELLULARITY CONNECTOME CYTOARCHITECTURE topological analysis multi-level imaging techniques 

分 类 号：Q942[生物学—植物学]