质子FLASH放疗  

Proton FLASH radiotherapy

作　　者：黄鑫[1] 张国梁 张春利 金晶 王绿化 彭浩[1] Huang Xin;Zhang Guoliang;Zhang Churtli;Jin Jing;Wang Lyuhua;Peng Hao(Department of Medical Physics,Wuhan University,Wuhan 430072,China;CNNC High Energy Equipment(Tianjin)Co.,Ltd,Tianjin 300300,China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,China)

机构地区：[1]武汉大学医学物理研究中心,430072 [2]中核高能(天津)装备有限公司,300300 [3]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院,100021 [4]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院,518116

出　　处：《中华放射肿瘤学杂志》2021年第9期968-974,共7页Chinese Journal of Radiation Oncology

摘　　要：FLASH放疗是一种在超高剂量率下进行的,具有与传统剂量率照射相似的肿瘤控制效果,并且减少正常组织和器官损伤的超快速放疗手段。由于其独特的放射生物学优势,FLASH放疗正受到学术界和工业界越来越多的关注,成为了当前放疗领域的前沿热点。结合质子治疗在布拉格峰上的剂量学优势和在三维方向上剂量的高度可控性,以及对细胞组织相对更高的穿透性,使得FLASH在质子治疗中的应用具备了更高的临床价值和更深远的意义。本文总结了目前已开展的质子FLASH照射实验,以及相关细胞和动物实验模型、实验条件和实验结果。同时,也探讨了质子FLASH效应可能的生物学机制,分析了质子FLASH放疗目前面临的挑战,并对其潜在的临床应用进行了展望。FLASH radiotherapy(FLASH-RT)is a treatment modality that delivers ultra-high dose rate and ultra-fast radiation for cancer treatment.Compared to conventional dose rate radiotherapy,FLASH-RT can yield similar efficacy for tumors and achieve normal tissue protection,translating to an increased therapeutic window.Due to this unique feature,FLASH-RT is attracting increasing attention from the radiotherapy community,both academia and industry.Due to its unique Bragg peak as well as intrinsic high dose rate,application of FLASH has more value and profound significance in proton therapy while achieving highly conformal dose deposition simultaneously.This article reviews research progress on FLASH-RT,relevant cell and animal studies,experimental conditions and results.Moreover,this article also investigates the potential biological mechanisms,technical challenges for implementation and potential clinical applications of FLASH-RT.

关 键 词：质子治疗 FLASH 剂量率 乏氧 

分 类 号：R730.55[医药卫生—肿瘤]