骨髓间充质干细胞线粒体转移与白血病细胞耐药  

Mitochondrial transfer of bone marrow mesenchymal stem cells and drug resistance of leukemia cells

作　　者：张利 郭铃 刘文君 ZHANG Li;GUO Ling;LIU Wen-jun(Department of Pediatrics,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Children Hematological Oncology and Birth Defects Laboratory,the Affiliated Hospital of Southwest Medical Universi-ty,Luzhou 646000,China;Sichuan Clinical Research Center for Birth Defects,Luzhou 646000,China)

机构地区：[1]西南医科大学附属医院儿科,泸州646000 [2]西南医科大学附属医院儿童血液肿瘤与出生缺陷实验室,泸州646000 [3]四川省出生缺陷临床医学研究中心,泸州646000

出　　处：《西南医科大学学报》2021年第5期476-483,共8页Journal of Southwest Medical University

基　　金：四川省应用基础研究项目(2019YJ0690);西南医科大学附属医院博士科研启动基金;四川省中医药管理局科学技术研究专项课题(2020JC0135)。

摘　　要：近年来发现,肿瘤细胞可以通过细胞间线粒体转移(mitochondrialtransfer)来维持其高代谢需求和高耐药性。骨髓间充质干细胞(bone marrowmesenchymalstemcells,BMSCs)可与白血病细胞之间发生线粒体转移,并促进白血病细胞的化疗耐药。本文就BMSCs与白血病细胞之间线粒体的转移、转移的触发信号、转移的途径及其与白血病细胞化疗耐药的关系做一综述,旨在为逆转白血病细胞耐药相关研究提供思路。In recent years,it has been discovered that tumor cells can maintain their high metabolic demand and high drug resistance through mitochondrial transfer between cells.Mitochondrial transfer can occur between bone marrow mesenchymal stem cells(BMSCs)and leukemia cells,promoting the chemotherapy resistance of leu⁃kemia cells.This article reviews mitochondrial transfer between BMSCs and leukemia cells,the triggering signals of the transfer,transfer pathways,and its relationship with the chemotherapy resistance of leukemia cells,aiming to provide ideas for research on reversing the drug resistance of leukemia cells.

关 键 词：线粒体转移 白血病 耐药性 骨髓间充质干细胞 转移途径 

分 类 号：R733.7[医药卫生—肿瘤]