阿立哌唑与喹硫平治疗老年期精神分裂症的疗效  

Efficacy of Aripiprazole and Quetiapine in the Treatment of Senile Schizophrenia

作　　者：李阳 LI Yang(Liaoning Mental Health Center,Tieling 112300,China)

机构地区：[1]辽宁省精神卫生中心,辽宁铁岭112300

出　　处：《中国医药指南》2021年第25期36-37,共2页Guide of China Medicine

摘　　要：目的探讨分析阿立哌唑与喹硫平治疗老年期精神分裂症的临床效果。方法随机选取2017年4月至2019年6月本院收治的96例老年期精神分裂患者,均分为48例观察组和48例对照组,对照组采用喹硫平药物进行治疗,观察组采用阿立哌唑药物进行治疗,对比分析两组患者治疗情况、治疗效果以及不良反应发生率。结果治疗后,观察组RBS评分(185.54±16.51)分、WCTS阴性量表(8.55±4.21)分、WCTS阳性量表(10.52±6.45)分,均分别优于对照组(153.01±9.39)分、(14.36±5.48)分、(15.88±5.37)分,有明显差异(P<0.05);观察组治疗有效22例、显效24例,总有效率95.83%,对照组治疗有效19例、显效18例,总有效率77.08%,观察组的总有效率显著高于对照组,有明显差异(P<0.05);观察组患者不良反应失眠1例(2.08%)、嗜睡2例(4.17%)、口干0例、头晕1例(2.08%)、便秘2例(4.17%)、恶心1例(2.08%),总发生率14.58%(7例),明显低于对照组的33.33%(16例),有明显差异(P<0.05)。结论阿立哌唑治疗老年期精神分裂症较喹硫平治疗临床效果更佳,能有效改善患者治疗情况,有助于不良反应发生率的降低,提高安全性。Objective To investigate and analyze the clinical effects of aripiprazole and quetiapine in the treatment of senile schizophrenia.Methods Ninety-Six elderly schizophrenic patients admitted to our hospital from April 2017 to June 2019 were randomly selected and divided into 48 observation groups and 48 control groups.The control group was treated with quetiapine and the observation group was treated with aripiprazole.The treatment situation,treatment effect and incidence of adverse reactions of the two groups were compared and analyzed.Results After treatment,RBS score(185.54±16.51)points,negative scale(8.55±4.21)points and positive scale(10.52±6.45)points in the observation group were better than those in the control group(153.01±9.39)points,(14.36±5.48)points and(15.88±5.37)points,there is a significant difference(P<0.05).The observation group had 22 cases of effective treatment and 24 cases of marked effect,with a total effective rate of 95.83%,while the control group had 19 cases of effective treatment and 18 cases of marked effect,with a total effective rate of 77.08%.The total effective rate of the observation group was significantly higher than that of the control group,there is a significant difference(P<0.05).In the observation group,1 patient suffered from insomnia(2.08%),2 patients suffered from somnolence(4.17%),0 patients suffered from dry mouth,1 patient suffered from dizziness(2.08%),2 patients suffered from constipation(4.17%),1 patient suffered from nausea(2.08%),and the total incidence rate was 14.58%(7 cases),which was significantly lower than 33.33%(16 cases)in the control group,there is a significant difference(P<0.05).Conclusion Aripiprazole is more effective than quetiapine in the treatment of senile schizophrenia.It can effectively improve the treatment of patients,reduce the incidence of adverse reactions and improve safety.

关 键 词：老年期精神分裂症 阿立哌唑 喹硫平 临床效果 不良反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学]