面向视网膜脱离手术的硅油填充模拟  

Simulations of silicone oil filling for use in retinal detachment surgery

作　　者：徐衍睿 班晓娟[1,2,3,4] 王笑琨 王宇[1,2,3,4] 尹豆[2,3] 周靖 黄厚斌 朱志鸿 XU Yan-rui;BAN Xiao-juan;WANG Xiao-kun;WANG Yu;YIN Dou;ZHOU Jing;HUANG Hou-bin;ZHU Zhi-hong(Beijing Advanced Innovation Center for Materials Genome Engineering,University of Science and Technology Beijing,Beijing 100083,China;School of Computer and Communication Engineering,University of Science and Technology Beijing,Beijing 100083,China;Institute of Artificial Intelligence,University of Science and Technology Beijing,Beijing 100083,China;Beijing Key Laboratory of Knowledge Engineering for Materials Science,University of Science and Technology Beijing,Beijing 100083,China;Hainan Hospital of PLA General Hospital,Sanya 572013,China)

机构地区：[1]北京科技大学北京材料基因工程高精尖创新中心,北京100083 [2]北京科技大学计算机与通信工程学院,北京100083 [3]北京科技大学人工智能研究院,北京100083 [4]北京科技大学材料领域知识工程北京市重点实验室,北京100083 [5]中国人民解放军总医院海南医院,三亚572013

出　　处：《工程科学学报》2021年第9期1233-1243,共11页Chinese Journal of Engineering

基　　金：海南省财政科技计划资助项目(ZDYF2020031,ZDYF2019009);国家自然科学基金资助项目(61873299);佛山市人民政府科技创新专项资金资助项目(BK20AF001,BK19AE034);中央高校基本科研基金资助项目(FRF-TP-19-043-A2)。

摘　　要：针对传统医疗手段无法有效量化评估手术中不同硅油加注量对于视网膜裂孔贴附效果的问题,本文提出一种面向视网膜脱离手术的硅油填充模拟方法,基于物理建模与计算机数值离散化技术对眼内受力、硅油填充状态进行分析,并对填充模拟过程进行三维模型构建与可视化,实现医疗过程决策辅助目的.首先对人类眼球与手术器具进行基础建模与模型采样,模拟手术流程中眼球状态;然后,根据水与硅油的密度、黏滞系数、表面张力等不同物理性质,对水‒硅油两相流动及交互进行模拟;最后,构建固液交互模型,实现多相液体在眼球中的运动与填充.实验结果表明,本文方法能够较好地呈现眼球内多相流体运动交互效果,实现了诸如表面张力、固液耦合、液体分层、连通器效应等效果,实现了对眼内腔中通过导管注入硅油与排出水分流程的模拟,为预测硅油填充后的眼内状态提供了一种有效的方式,辅助医生进行手术流程规划与效果预测.With advancements in modern medical technology,the treatment of rhegmatogenous retinal detachment has been receiving increasing attention.Globally,vitrectomy combined with intraocular silicone oil tamponade has been widely used for rhegmatogenous retinal detachment,and the surgical equipment and technology required are increasingly advanced.In such an operation,it is crucial to understand how to achieve the best therapeutic effect with the minimum amount of silicone oil tamponade so as to reduce surgical complications.Traditional medical methods cannot effectively evaluate the effect of different silicone oil dosages on retinal hole attachment.Aiming at this concern,the current study proposed a silicone oil tamponade simulation method for retinal detachment surgery.Based on physical modeling and computer numerical discretization techniques,the intraocular force and silicone oil filling state were analyzed.Three-dimensional modeling and simulation of the silicone tamponade process were then conducted and visualized to help with medical decision-making.First,the human eyeball and surgical instruments were modeled and sampled to simulate the eyeball state during the operation.Second,based on differences in density,viscosity coefficient,and surface tension between water and silicone oil,the two-phase flow and water‒silicone oil interaction were simulated.Finally,the solid‒liquid interaction model was constructed to assess the movement and injection process of multiphase liquid in the eyeball.The experimental results show that this method can well present the interaction effect of multiphase fluid movement in the eyeball;understand effects such as surface tension,solid-liquid coupling,liquid stratification,and connector effect;and realize the simulation of the silicone oil injection and water drainage processes through the catheter in the intraocular cavity,which provides an effective way to predict the intraocular state after silicone oil filling and assists doctors in the field of operation process planning and

关 键 词：孔源性视网膜脱离 硅油填充 流体模拟 多相流 固液边界 

分 类 号：R774.1[医药卫生—眼科] TP399[医药卫生—临床医学]