胃癌患者第三腰椎平面骨骼肌指数与术前外周血炎性因子等指标的相关性分析  

Correlation analysis of third lumbar skeletal muscle index and inflammatory factors and other factors in peripheral blood in gastric cancer patients

作　　者：沈小丁 万谦益 王勇[1] 赵锐[1] 伍羽韬 赵李澔 伍晓汀[1] Shen Xiaoding;Wan Qianyi;Wang Yong;Zhao Rui;Wu Yutao;Zhao Lihao;Wu Xiaoting(Department of Gastrointestinal Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;West China School of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院胃肠外科,成都610041 [2]四川大学华西口腔医学院,成都610041

出　　处：《中华临床营养杂志》2021年第2期65-68,共4页Chinese Journal of Clinical Nutrition

摘　　要：目的探究胃癌患者术前第三腰椎平面骨骼肌指数(L3 skeletal muscle index,LSMI)与术前外周血炎性因子等指标的相关性。方法回顾性分析2017年10月至2019年12月期间四川大学华西医院胃肠外科收治的胃癌患者,基于术前腹部CT影像学数据,将第三腰椎平面骨骼肌面积(cm^(2))除以身高的平方(m^(2)),得到归一化的LSMI(cm^(2)/m^(2))。采用Person相关性分析分析胃癌患者术前LSMI与术前外周血炎性因子等指标的相关性。结果研究共纳入胃癌患者132例,其中病理分期Ⅰ期患者39例,Ⅱ期患者36例,Ⅲ期患者57例。Pearson相关分析提示胃癌患者LSMI与外周血红细胞计数(P<0.01)、血红蛋白(P<0.01)及前白蛋白(P<0.01)呈正相关,与白细胞介素6(P=0.027)和C反应蛋白(P=0.014)呈负相关。结论LSMI可作为胃癌患者营养状况评定指标,而炎性因子白细胞介素-6和C反应蛋白在胃癌患者中肌减少症的发生、发展中起着重要作用。Objective To study the correlation between third lumbar skeletal muscle index(LSMI)and inflammatory factors and other factors in peripheral blood in gastric cancer patients.Methods From October 2017 to December 2019,patients with gastric cancer admitted to West China Hospital Sichuan University were included.The LSMI of patients was obtained by dividing the area of skeletal muscle at the third lumbar vertebra level by the square of the height based on preoperative abdominal imaging data.The correlation between preoperative LSMI and inflammatory factors and other factors in peripheral blood were analyzed by person correlation analysis.Results This study included 132 patients with gastric cancer.Among them,39 were classified as stageⅠ,36 were stageⅡ,and 57 were stageⅢ,respectively.Pearson correlation analysis suggested that the LSMI of gastric cancer patients was positively correlated with peripheral red blood cell count(P<0.01),hemoglobin(P<0.01),and prealbumin(P<0.01),and negatively correlated with interleukin-6(IL-6,P=0.027)and C-reactive protein(CRP,P=0.014).Conclusion Our study suggested that LSMI can be used as a nutritional index in gastric cancer patients and IL-6 and CRP played an important in the occurrence and development of sarcopenia in gastric cancer patients.

关 键 词：胃癌 肌减少症 营养指标 炎性因子 

分 类 号：R735.2[医药卫生—肿瘤]