HER-2蛋白表达与多层螺旋CT胃癌征象相关性分析及应用  

Correlation Analysis and Clinical Application of HER-2 Protein Expression with Multi-slice Spiral CT Signs of Gastric Cancer

作　　者：李玉珠 李亚平 李彦良[2] LI Yuzhu;LI Yaping;LI Yanliang(Department of General Surgery,Zhaoyuan People’s Hospital,Zhaoyuan 265499,Shandong,P.R.China;Department of Gastrointestinal Tumor,Shandong Cancer Hospital,Jinan 250000,Shandong,P.R.China)

机构地区：[1]招远市人民医院普通外科一病区,山东招远265499 [2]山东省肿瘤医院胃肠肿瘤外科,山东济南250000

出　　处：《影像科学与光化学》2021年第5期684-688,共5页Imaging Science and Photochemistry

摘　　要：本研究探讨人类表皮生长因子受体-2(HER-2)蛋白表达与多层螺旋CT(MSCT)胃癌征象的关系。采用回顾性研究方法,选取胃癌患者134例,采用免疫组化染色法检测HER-2表达情况,分析HER-2表达与临床病理及MSCT征象关系。结果显示,高分化组织HER-2阳性表达率为57.41%,高于中低分化组织(P<0.05);有淋巴结转移组织HER-2阳性表达率为48.28%,高于无淋巴结转移组织(P<0.05);HER-2阳性表达病灶静脉期CT值为(87.82±14.45)HU,明显低于HER-2阴性表达病灶(P<0.05);HER-2表达(+++)组织高分化比例为84.62%,高于HER-2表达(++)组织(P<0.05)。研究证实HER-2蛋白表达胃癌分化、淋巴结转移有一定关系,同时与MSCT静脉期CT值有关。The purpose of this study was to investigate the relationship between the expression of human epidermal growth factor receptor-2(HER-2)protein and multi-slice spiral CT(MSCT)signs of gastric cancer.A retrospective study was conducted,134 cases of gastric cancer patients were selected,the expression of HER-2 was detected by immunohistochemical staining,and the relationship between HER-2 expression and clinicopathological and MSCT signs was analyzed.The results show that the positive expression rate of HER-2 in high differentiated tissues was 57.41%,which was higher than that in low and moderately differentiated tissues(P<0.05).The positive expression rate of HER-2 in tissues with lymph node metastasis was 48.28%,which was higher than that in tissues without lymph node metastasis(P<0.05).The CT value of HER-2 positive expression lesions in venous phase was(87.82±14.45)HU,which was significantly lower than that of HER-2 negative expression lesions(P<0.05).The proportion of highly differentiated tissues with HER-2 expression(+++)was 84.62%,which was higher than that of HER-2(++)(P<0.05).This study confirmed that HER-2 protein expression is related to gastric cancer differentiation and lymph node metastasis,and is related to the CT value of MSCT venous phase.

关 键 词：人类表皮生长因子受体-2 多层螺旋CT 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]