单眼病变引起双侧眼表结构功能改变的研究进展  

Advances in bilateral alterations of ocular surface structure and function after monocular lesions

作　　者：魏巧(综述) 李鸿(审校)[1] WEI Qiao;LI Hong(Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一院眼科,400016

出　　处：《重庆医学》2021年第17期3036-3040,3045,共6页Chongqing medicine

基　　金：国家自然科学基金项目(81770913、81974131)。

摘　　要：双眼在解剖上看似独立,但在病理生理上相互关联、相互影响。近年来研究显示单眼病变患者的对侧未受累眼存在与患眼相似的眼表结构及功能改变,如角膜神经密度降低、角膜感觉功能减退、角膜细胞减少、泪液分泌减少、泪液因子改变、树突状细胞增多和眼表免疫赦免特性丧失。该文将对单眼病变引起的双侧眼表变化及其发病机制作一综述,以期加深对双眼间关系的认识。Each of the two eyes in humans is encased separately within its bony orbit,and there is no anatomical communication between the two compartments.However they are correlated and influenced by each other in pathophysiology.Recent studies have shown the contralateral unaffected eye of patients with monocular lesions has ocular surface structural and functional changes,which are similar to affected eye,such as the reduction of corneal nerves、the loss of corneal sensation、a diminishment of corneal superficial epithelial cells、corneal endothelial cells and tear secretion、the change of tear cytokines、increased density of dendritic cells and the loss of immune privilege.This article reviews the bilateral changes of ocular surface structure and function and its pathogenesis caused by monocular lesions,hoping for deepening the understanding of binocular relationship.

关 键 词：对侧未受累眼 角膜神经 角膜细胞 树突状细胞 泪液 综述 

分 类 号：R772.2[医药卫生—眼科]