肝硬化食管胃静脉曲张出血患者胃镜治疗术后再出血的影响因素分析  

Influencing factors of rebleeding after gastroscopy in patients with liver cirrhosis and esophagogastric variceal bleeding

作　　者：连佳[1] 韩涛[1] 向慧玲[1] 杨言开[1] 李庭红[1] 刘磊[1] 徐佰国[1] 孙立霞 王菲 付彦超[1] LIAN Jia;HAN Tao;XIANG Huiling;YANG Yankai;LI Tinghong;LIU Lei;XU Baiguo;SUN Lixia;WANG Fei;FU Yanchao(Department of Hepatology,Tianjin Third Central Hospital,The Third Central Clinical College of Tianjin Medical University,Tianjin Institute of Hepatobiliary Disease,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院消化肝病科,天津医科大学三中心临床学院,天津市肝胆疾病研究所,天津300170

出　　处：《临床肝胆病杂志》2021年第9期2092-2096,共5页Journal of Clinical Hepatology

基　　金：国家艾滋病和病毒性肝炎等重大传染病防治科技专项课题(2017ZX10203202)。

摘　　要：目的分析肝硬化食管胃静脉曲张出血患者胃镜治疗术后再出血的影响因素。方法回顾性分析2017年1月1日—2018年12月31日于天津市第三中心医院住院的肝硬化食管胃静脉曲张出血并行胃镜治疗的患者临床资料,依据是否发生再出血及出血时间,分为未出血组(n=148)与出血组(n=119),分析影响胃镜治疗术后再出血的危险因素。计量资料两组间比较采用t检验或Mann-Whitney U秩和检验;计数资料两组间比较采用χ2检验。采用Cox回归模型进行单因素及多因素分析。应用受试者工作特征(ROC)曲线评估Child-Turcotte-Pugh(CTP)评分、肝纤维化4因子指数(FIB-4)、白蛋白-胆红素(ALBI)评分预测胃镜治疗术后再出血的准确性;使用MedCalc软件比较ROC曲线下面积(AUC)的差异。结果共纳入267例肝硬化食管胃静脉曲张出血患者,其中合并肝癌患者53例(19.9%)。119例患者发生再出血,总再出血率为44.6%,中位再出血时间为11.0(0~39.0)个月。Cox单因素分析结果显示肝癌(HR=0.377,P<0.001)、AST(HR=1.002,P=0.025)、血Na(HR=0.935,P=0.004)、FIB-4(HR=1.030,P=0.049)均与再出血相关;Cox多因素分析结果显示肝癌(HR=0.357,P<0.001)、AST(HR=1.003,P=0.030)、PT(HR=0.196,P=0.001)、CTP(HR=1.289,P=0.014)、FIB-4(HR=1.062,P=0.033)、ALBI(HR=0.433,P=0.011)均是再出血的独立影响因素。CTP、FIB-4、ALBI评分预测再出血的AUC分别为0.711(95%CI:0.647~0.776)、0.705(95%CI:0.640~0.770)、0.730(95%CI:0.667~0.793)。CTP、FIB-4、ALBI 3个评分的AUC比较,差异均无统计学意义(P值均>0.05)。结论肝硬化食管胃静脉曲张出血行胃镜治疗的患者,肝癌、AST、PT、CTP、FIB-4、ALBI均与胃镜治疗术后再出血有关,其中CTP、FIB-4、ALBI 3项评分对再出血结局均有很好的预测价值,且预测能力无差异。Objective To investigate the influencing factors for rebleeding after gastroscopy in patients with liver cirrhosis and esophagogastric variceal bleeding.Methods A retrospective analysis was performed for the clinical data of the patients with liver cirrhosis and esophagogastric variceal bleeding who were hospitalized in Tianjin Third Central Hospital from January 1,2017 to December 31,2018,and according to the presence or absence of rebleeding and bleeding time,the patients were divided into non-bleeding group(n=148)and bleeding group(n=119).The risk factors for rebleeding after gastroscopy were analyzed.The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups,and the chi-square test was used for comparison of categorical data between two groups.The Cox regression model was used for univariate and multivariate analyses.The receiver operating characteristic(ROC)curve was used to evaluate the accuracy of Child-Turcotte-Pugh(CTP),fibrosis-4(FIB-4),and albumin-bilirubin(ALBI)scores in predicting rebleeding after gastroscopy,and MedCalc was used to compare the area under the ROC curve(AUC).Results A total of 267 patients with liver cirrhosis and esophagogastric variceal bleeding were enrolled,among whom 53(19.9%)had liver cancer.A total of 119 patients suffered from rebleeding,with an overall rebleeding rate of 44.6%and a median time to rebleeding of 11.0(0-39.0)months.The univariate Cox regression analysis showed that liver cancer(hazard ratio[HR]=0.377,P<0.001),aspartate aminotransferase(AST)(HR=1.002,P=0.025),serum Na(HR=0.935,P=0.004),and FIB-4(HR=1.030,P=0.049)were associated with rebleeding,and the multivariate Cox regression analysis showed that liver cancer(HR=0.357,P<0.001),AST(HR=1.003,P=0.030),prothrombin time(PT)(HR=0.196,P=0.001),CTP score(HR=1.289,P=0.014),FIB-4(HR=1.062,P=0.033),and ALBI score(HR=0.433,P=0.011)were independent risk factors for rebleeding.CTP,FIB-4,and ALBI scores had an AUC of 0.711(95%confidence interval[CI]:0.647-0.776),0.705(95%CI:0.640-0.77

关 键 词：肝硬化 食管和胃静脉曲张 胃镜检查 再出血 影响因素分析 

分 类 号：R575.2[医药卫生—消化系统]