癫痫患儿兴奋性及抑制性神经递质的表达变化及与严重程度的关系探究  

Investigation on Expression Change of Excitatory and Inhibitory Neurotransmitters of Children with Epilepsy and Correlation with Severity

作　　者：申延丰[1] 齐茗馨 梁军[1] 张桂香[1] SHEN Yanfeng;QI Mingxin;LIANG Jun;ZHANG Guixiang(Dalian Children’s Hospital,Dalian 116012,China;不详)

机构地区：[1]辽宁省大连市儿童医院,辽宁大连116012

出　　处：《中国医学创新》2021年第21期175-179,共5页Medical Innovation of China

摘　　要：目的:探究癫痫患儿兴奋性及抑制性神经递质的表达变化及与严重程度的关系。方法:选取2018年1月-2019年12月本院收治的90例癫痫患儿为观察组,同时期的90例健康儿童为对照组。比较两组血清兴奋性神经递质(5-HT、Glu及Ach)及抑制性神经递质(GABA、Gly及Ala)水平,同时比较观察组中不同STESS评分及发作持续时间患者的检测结果,并采用Spearman秩相关分析上述检测指标与STESS评分及发作持续时间的关系。结果:观察组血清兴奋性神经递质均显著高于对照组,血清抑制性神经递质均显著低于对照组,且观察组中STESS评分较高及发作持续时间较长患者血清兴奋性神经递质显著高于STESS评分较低及发作持续时间较短患者,血清抑制性神经递质显著低于STESS评分较低及发作持续时间较短患者,差异均有统计学意义(P<0.05)。Spearman秩相关分析显示,血清兴奋性神经递质与STESS评分及发作持续时间均呈正相关(P<0.05),血清抑制性神经递质与STESS评分及发作持续时间均呈负相关(P<0.05)。结论:癫痫患儿兴奋性及抑制性神经递质的表达显著异常,且与严重程度有密切的关系,因此检测价值较高。Objective:To investigate the expression change of excitatory and inhibitory neurotransmitters of children with epilepsy and correlation with severity.Method:A total of 90 children with epilepsy from January 2018 to December 2019 were chosen as the observation group,90 healthy children at the same time were chosen as the control group.Then the serum excitatory neurotransmitters (5-HT,Glu and Ach) and inhibitory neurotransmitters (GABA,Gly and Ala) of two groups were compared,and the detection results of the observation group with different STESS scores and duration of attack were compared,then the correlation between those detection indexes and TESS scores,duration of attack were analyzed with Spearman rank correlation analysis.Result:The serum excitatory neurotransmitters of the observation group were significantly higher than those of the control group,the serum inhibitory neurotransmitters were significantly lower than those of the control group,and the serum excitatory neurotransmitters of the observation group with higher TESS scores and longer duration of attack were significantly higher than those of patients with lower TESS scores and shorter duration of attack,the serum inhibitory neurotransmitters were significantly lower than those of patients with lower TESS scores and shorter duration of attack,there were statistically significant differences (P<0.05).Spearman rank correlation analysis showed the serum excitatory neurotransmitters were positively correlated with TESS scores and duration of attack (P<0.05),the serum inhibitory neurotransmitters were negatively correlated with TESS scores and duration of attack (P<0.05).Conclusion:The expression of excitatory and inhibitory neurotransmitters of children with epilepsy are significantly abnormal,and they are close correlated with severity,so their detection value are higher.

关 键 词：癫痫患儿 兴奋性神经递质 抑制性神经递质 严重程度 

分 类 号：R742.1[医药卫生—神经病学与精神病学]