双(2-羟基-1-萘甲醛)缩N,N'-二(3-氨基丙基)哌嗪Schiff碱的合成、表征及抑菌活性  

SYNTHESIS,CHARACTERIZATION AND ANTIBACTERIAL ACTIVITIES OF BIS-(2-HYDROXYL-1-NAPHTHADEHYDE)-[N,N'-BIS(3-AMINOPROPYL)-PIPERAZINE]SCHIFF BASE

作　　者：佟萍 刘泽含 刘春风 王瑞 李凡凡 杨杨 杨迎晨 许瑞波 TONG Ping;LIU Ze-han#;LIU Chun-feng;WANG Rui;LI Fan-fan;YANG Yang;YANG Ying-chen;XU Rui-bo(Pharmacy School,Jiangsu Ocean University,Lianyungang,Jiangsu 222005,China;Jiangsu Lvyuan Engineering Design&Research CO.LTD.,Lianyungang,Jiangsu 222007,China;Jiangsu Institute of Marine Resources Development Research,Lianyungang,Jiangsu 222005,China)

机构地区：[1]江苏海洋大学药学院,江苏连云港222005 [2]江苏绿源工程设计研究有限公司,江苏连云港222007 [3]江苏省海洋资源开发研究院.,江苏连云港222005

出　　处：《井冈山大学学报（自然科学版）》2021年第4期23-27,70,共6页Journal of Jinggangshan University (Natural Science)

基　　金：江苏省高等学校自然科学研究项目(19KJA430008);江苏连云港市2017年度海燕计划和连云港市第五期“521”工程项目;江苏省海洋资源开发研究院开放课题(JSIMR201901、JSIMR201902).;大学生实践创新训练计划项目(201811641319、SY202011641319002、X201911641319002)。

摘　　要：以N,N'-二(3-氨基丙基)哌嗪、2-羟基-1-萘甲醛为原料,通过缩合反应得到双Schiff碱,双(2-羟基-1-萘甲醛)缩N,N'-二(3-氨基丙基)哌嗪。研究了溶剂、反应时间、温度等因素对产率的影响,得到最佳合成工艺条件为:乙醇为反应溶剂,反应温度60℃,反应时间4 h,产物分离收率约92%。利用熔点、IR、UV-vis、1H NMR等手段对产物结构进行了表征。此外,采用琼脂扩散平板抑菌法测定了其对金黄色葡萄球菌、大肠杆菌的抑制作用,发现具有一定抑菌活性。Schiff base compound bis-(2-hydroxyl-1-naphthaldehyde)-[N,N'-bis(3-aminopropyl)piperazine]was synthesized by the condensation reaction of N,N'-bis(3-aminopropyl)piperazine and 2-hydroxyl-1-naphthaldehyde.The effects of solvent types,reaction temperature and reaction time on the yield of the title product were studied by single factor experiments,and the optimal conditions were obtained as followed:solvent was ethanol,reaction temperature was 60℃,reaction time was 4 h,and the product yield was about 92%.The structure of the product was characterized by the methods of melting point,IR,UV-vis and 1H NMR.Moreover,the antibacterial effect of the product against Staphyloccus aureus and Escherichia coli was investigated by agar diffusion method,which.indicated that they had certain antibacterial activities.

关 键 词：2-羟基-1-萘甲醛 N N'-二(3-氨基丙基)哌嗪 双Schiff碱 最佳工艺条件 抑菌活性 

分 类 号：O625.63[理学—有机化学]