移动多媒体记忆疗法在减轻阿尔茨海默病患者行为和心理症状中的应用  

Applications of mobile multimedia memory therapy in alleviating behavioral and psychological symptoms of patients with Alzheimer disease

作　　者：李彦玲 王修 单淑珍[1] 王威[3] LI Yan-ling;WANG Xiu;SHAN Shu-zhen;WANG Wei(Department of Neurology,Xinhua Hospital Affiliated to Dalian University,Liaoning Province,Dalian 116021,China;Graduate School,Dalian University,Liaoning Province,Dalian 116022,China;Department of Rehabilitation,Zhongshan Hospital Affiliated to Dalian University,Liaoning Province,Dalian 116001,China)

机构地区：[1]大连大学附属新华医院神经内科,辽宁大连116021 [2]大连大学研究生院,辽宁大连116022 [3]大连大学附属中山医院康复科,辽宁大连116001

出　　处：《中国当代医药》2021年第25期266-269,共4页China Modern Medicine

基　　金：辽宁省大连市医学科学研究计划项目(2011020)。

摘　　要：目的观察移动多媒体记忆疗法在减轻阿尔茨海默病(AD)患者行为和心理症状中的疗效。方法选取2016年4月—2019年4月大连大学附属新华医院收治的100例AD患者作为研究对象,采用抽签法随机分为试验组和对照组,每组各50例。对照组给予盐酸美金刚片10 mg/次,2次/d,疗程16周,试验组在对照组基础上给予多媒体记忆疗法。用简易精神状态检查(MMSE)测量认知功能、神经精神科问卷(NPI)测量行为和心理症状(BPSD),两组治疗前及治疗16周末进行测评,并进行比较。结果试验组16周治疗后的MMSE评分高于治疗前,且试验组的MMSE评分高于对照组,差异均有统计学意义(P<0.05)。两组16周治疗后的NPI中的激越/攻击、抑郁/心境恶劣、焦虑方面评分低于治疗前,差异均有统计学意义(P<0.05)。结论移动多媒体记忆疗法可减轻AD,可以改善精神行为症状,值得临床推广应用。Objective To investigate the role of mobile multimedia memory therapy in alleviating Alzheimer′s Disease(AD).Methods A total of 100 AD patients admitted to Xinhua Hospital Affiliated to Dalian University from April 2016 to April 2019 were selected as the research objects,and were divided into the experimental group and the control group by drawing lots,50 cesas in each group.The control group was given memantine tablets 10 mg/time,2 times/d,for 16 weeks,and the experimental group was given multimedia memory therapy on the basis of the control group.The mini-mental stateamination(MMSE)was used to measure cognitive function.The neuropsychiatric inventory(NPI)was used to measure the behavioral and psychological symptoms of dementia(BPSD).The evaluation results of MMSE and NPI scales were compared between the two groups before treatment and at the end of the 16th week.Results The MMSE scores of the experimental group after 16 weeks of treatment were higher than before treatment,the MMSE scores of the experimental group was higher than that of the control group,the differences were statistically significant(P<0.05).After 16 weeks of treatment,the indicators of agitation/aggression,depression/dysthymia,and anxiety in the experimental group were lower than those before treatment,the differences were statistically significant(P<0.05).Conclusions Mobile multimedia memory therapy could be used for alleviating AD and improving mental and behavioral symptoms.This therapy could be recommended for clinical application.

关 键 词：记忆疗法 阿尔茨海默病 精神行为症状 认知功能 

分 类 号：R749.16[医药卫生—神经病学与精神病学]