多种肿瘤标志物联合检测对卵巢癌术后复发的早期诊断价值  

Predicting Value of Combined Detection of Multiple Tumor Markers in the Early Diagnosis of Postoperative Recurrence of Ovarian Cancer

作　　者：陈燕 郭玉格 CHEN Yan;GUO Yu-ge(Department of Obstetrics and Gynecology,Shangnan County Maternal and Child Health Hospital,Shangluo 726300)

机构地区：[1]陕西省商南县妇幼保健院妇产科,陕西商洛726300 [2]杨凌示范区医院妇产科,陕西杨凌712100

出　　处：《医学临床研究》2021年第8期1149-1151,1155,共4页Journal of Clinical Research

基　　金：中华国际科学交流基金会项目(Z2019LSXE008)。

摘　　要：【目的】探讨多种肿瘤标志物联合检测处卵巢癌术后复发的早期诊断价值。【方法】选取陕西省商南县妇幼保健院2016年1月至2019年2月收治的104例经影像学检查、临床表现等疑似盆腹腔复发的卵巢癌患者为研究对象,采用电化学发光免疫测定法测定患者血清癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)水平,采用酶联免疫吸附法测定血清人附睾蛋白4(HE4)水平。建立ROC曲线,计算曲线下面积(AUC),分析血清CEA、HE4、CA125、CA199的独立检测与联合检测对卵巢癌复发的诊断价值。【结果】104例疑似卵巢癌盆腹腔复发患者,经病理证实共80例盆腹腔复发,24例未复发。盆腹腔复发患者CEA、CA125、CA199、HE4水平均高于未复发者(P<0.05)。联合检测卵巢癌复发、转移诊断的AUC为0.950,敏感性为95.71%,特异性为80.00%,阳性似然比为4.79,明显高于各指标单一检测(P<0.05)。【结论】血清CEA、HE4、CA125、CA199联合检测可有效地提高卵巢癌早期复发的诊断率,对临床治疗具有十分重要的意义。【Objective】To explore the value of combined detection of multiple tumor markers in the early diagnosis of postoperative recurrence of ovarian cancer.【Methods】A total of 104 patients with ovarian cancer suspected of recurrence in the pelvic and abdominal cavity who were admitted to our hospital from January 2016 to February 2019 were selected as the research subject.Serum carcinoembryonic antigen(CEA)was determined by electrochemiluminescence immunoassay.Levels of carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199)and serum human epididymal protein 4(HE4)were determined by enzyme-linked immunosorbent assay.The ROC curve was used to calculate the area under the curve(AUC)and to analyze the diagnostic value of the independent and combined detection of serum CEA,HE4,CA125,and CA199 for the recurrence of ovarian cancer.【Results】Of 104 patients with suspected pelvic and abdominal cavity recurrence,a total of 80 patients were confirmed pathologically with pelvic and abdominal cavity recurrence,and 24 patients did not relapse.CEA,CA125,and CA199 levels of patients with pelvic and abdominal cavity recurrence were higher than those of non-recurring patients(P<0.05).The AUC of the combined detection of recurrence and metastasis of ovarian cancer was 0.950,the sensitivity was 95.71%,the specificity was 80.00%,and the positive likelihood ratio was 4.79,which was significantly higher than the single detection o£each index(P<0.05).【Conclusion】The combined detection of serum CEA,HE4,CA125,and CA199 can effectively improve the diagnosis rate and has very important diagnostic significance for early recurrence of ovarian cancer.

关 键 词：卵巢肿瘤/诊断 CA-125抗原/血液 癌胚抗原/血液 附睾分泌蛋白质类/血液 CA-19-9抗原/血液 生物标记 肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]