碘离子转运体及其调控通路在肿瘤机制研究中的相关进展  

Research progress of the role of iodide transporters and its regulatory signal pathways in carcinomas

作　　者：黄凤艳 肖娟[2] 肖强 王丽华 贾红英[1,2] Huang Fengyan;Xiao Juan;Xiao Qiang;Wang Lihua;Jia Hongying(Department of Epidemiology and Health Statistics,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,China;The Second Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250033,China)

机构地区：[1]山东大学公共卫生学院流行病与卫生统计学系,济南250012 [2]山东大学第二医院,济南250033

出　　处：《中华劳动卫生职业病杂志》2021年第8期635-640,共6页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：甲状腺滤泡上皮细胞基底膜上的碘离子转运体可参与并介导细胞内外碘离子流动。机体众多含碘组织中,仅甲状腺滤泡上皮细胞内胶体的碘离子可被作为原料,经氧化、碘化、偶联而合成甲状腺激素(thyroid hormone,TH)以发挥生理功能。因此,碘离子转运体的碘转运功能对TH的生物合成至关重要。此外,功能学研究表明,碘离子转运体作为离子通道蛋白,其表达异常或功能丧失可作为肿瘤促进因子或抑制因子参与mTOR信号通路、MAPKs信号通路、以及NF-κB信号通路的调节,进而调控癌细胞增殖、浸润、转移和凋亡,以发挥非碘转运作用。因此,碘离子转运体的非碘转运功能对肿瘤发生进展至关重要。本文就经典碘离子转运体,钠/碘协同转运体(sodium iodide symporter,NIS)和阴离子交换体(pendrin),及新型碘离子转运体,囊性纤维化跨膜电导调节器(cystic fibrosis transmembrane conductance regulator,CFTR)、钠复合维生素转运体(sodium multivitamin transporter,SMVT)、钙激活氯通道蛋白(anoctamin 1,ANO1)的碘转运功能以及非碘转运功能。在肿瘤发生进展中的作用,及其相关调控信号通路的研究进展进行综述,以期为全面阐明碘离子转运体及其调控信号通路在癌症发生进展中的作用机制提供理论依据和文献总结参考。Iodine transporters of basement membrane of thyroid follicular epithelial cells can participate and exchange the iodine ions across intracellular and extracellular.Among all of the iodine rich organs,iodine ions which only exist in colloidal of thyroid follicular epithelial cells can be functioned as the raw materials,which after oxidation,iodization and coupling,to synthesize thyroid hormone(TH)and to exert its biological functions.Therefore,the iodine transported function of iodide transporters plays a pivotal role for TH biosynthesis.Furthermore,functional studies show that the abnormal expression or dysfunction of iodide transporters might serves as tumor promoters or inhibitors via regulated the mTOR signal pathway,the MAPKs signal pathway,and the NF-κB signal pathway,together contributed to the regulation of cell proliferation,invasion,metastasis and apoptosis,in which plays the role of non iodide transported function.Therefore,the non iodine transported function of iodide transporters may plays the crucial role of tumor occurrence and progression of carcinoma.Based on this information,present study was devoted to systematic summarize the iodine transported function and non iodine transported function(may affects occurrence and progression of carcinoma)of the classical iodide transporters[sodium iodide symporter(NIS)and pendrin]and novel iodine transporters[(cystic fibrosis transmembrane conductance regulator(CFTR),sodium multivitamin transporter(SMVT),and anoctamin 1(ANO1)],respectively,in order to provide a theoretical basis and literature review reference for underlying the mechanism of iodine transporters and its regulated signal pathways for the occurrence and progression of carcinomas.

关 键 词：碘 离子 甲状腺激素类 转运体 信号通路 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]