重庆市永川地区人群甲状腺结节与尿碘关系  

Relationship between thyroid nodules and urinary iodine in Yongchuan area of Chongqing

作　　者：张顺琼[1] 曾泥 段绪琼 谯捷 何建华[1] 肖邦忠[2] ZHANG Shun-qiong;ZENG Ni;DUAN Xu-qiong;QIAO Jie;HE Jian-hua;XIAO Bang-zhong(Yongchuan Hospital Affiliated to Chongqing Medical University,Chongqing 402160,China;不详)

机构地区：[1]重庆医科大学附属永川医院,重庆402160 [2]重庆市疾病预防控制中心

出　　处：《中国地方病防治》2021年第4期308-310,共3页Chinese Journal of Control of Endemic Diseases

基　　金：永川区自然科学基金计划项目(Ycstc,2018nb0225)。

摘　　要：目的探索重庆市永川地区人群甲状腺结节患病情况与尿碘的关系,为制定防控方案提供依据。方法结合人群健康体检,选择过去半年未使用含碘制剂及近10日内未食用海水产品者作为检查对象;采用B超检查甲状腺;采集尿液检测尿碘;用χ^(2)检验计数资料显著性,以P<0.05为差异有统计学意义。结果共检查775人,年龄为18~80岁,平均为44.18岁。检出甲状腺结节患者261例,甲状腺结节患病率为33.68%。女性患病率(45.36%)显著高于男性(21.96%)(χ^(2)=36.78>7.88,P<0.005);随着年龄的增长患病率显著升高(χ^(2)均>7.88/3.84,P<0.005/0.05),30~岁组(18.80%)最低,50~岁组(47.41%)最高。尿碘中位数为174.85μg/L,<100μg/L占19.48%,100~199μg/L占40.77%,200~μg/L和300~μg/L占39.74%;甲状腺结节患病率与尿碘水平呈"U"型曲线关系,尿碘150~199μg/L患病率(20.00%)显著低于<100μg/L两个组(47.45%、47.82%)和≥200μg/L三个组(30.30%、40.54%、49.01%)(χ^(2)均>3.84/7.88,P<0.05/0.005)。结论重庆市永川地区人群甲状腺结节患病率与尿碘呈"U"型曲线关系,碘缺乏与碘超适宜及过量均是影响甲状腺结节患病率升高的因素。Objective To explore the relationship between the prevalence of thyroid nodule and urinary iodine in Yongchuan area of Chongqing,and provide scientific basis for prevention and control plans.Method The subjects who had not used iodine-containing preparations in the past 1 year,also had not eaten sea-products in the past 10 days were selected as the subjects.Ultrasound was used to examine thyroid gland.Urine test was used to examine urinary iodine.χ^(2)test was used to test the significance of the count data,and P<0.05 was considered to be significant.Results A total of 775 patients were examined,aged 18-80,the average age was 44.18 years old,261 patients with thyroid nodules were detected,the prevalence of thyroid nodule was 33.68%.The prevalence of female(45.36%)was significantly higher than that of male(21.96%)(χ^(2)=36.78>7.88,P<0.005);The prevalence increased significantly with age(χ^(2)>7.88/3.84,P<0.005/0.05),the 30-year-old group(18.80%)was the lowest,and the 50-year-old group(47.41%)was the highest.The median urine iodine was 174.85μg/L,<100μg/L accounted for 19.48%,100-199μg/L accounted for 40.77%,200μg/L and 300μg/L above accounted for 39.74%;The prevalence of thyroid nodules and urine iodine level showed a"U"curve relationship.The prevalence of urinary iodine 150-199μg/L(20.00%)was significantly lower than the two groups<100μg/L(47.45%,47.82%)and≥200μg/L three groups(30.30%,40.54%,49.01%)(χ^(2) both>3.84/7.88,P<0.05/0.005).Conclusion The prevalence of thyroid nodules and urinary iodine in Yongchuan area of Chongqing shows a U-shaped curve.The iodine deficiency,over-adequacy and excess are all factors that affect the increase in the prevalence of thyroid nodules.

关 键 词：甲状腺结节 患病率 尿碘 

分 类 号：R581[医药卫生—内分泌]