二氯化锶联合局部放疗治疗多发性骨转移癌的临床研究  

Clinical Study of Strontium Dichloride (^(89)SrCl^(2)) Combined with Local Radiotherapy in the Treatment of Multiple Bone Metastases

作　　者：孙东兵 SUN Dongbing(Department of Nuclear Medicine,Shanxian County Central Hospital,Heze,Shandong Province,274300 China)

机构地区：[1]山东省单县中心医院核医学科,山东菏泽274300

出　　处：《中外医疗》2021年第21期97-100,共4页China & Foreign Medical Treatment

摘　　要：目的以多发性骨转移癌为判定对象,探究二氯化锶(89SrCl2)与局部放射共同治疗的效果情况。方法随机选取2017年1月—2020年1月该院接收的50例多发性骨转移癌者为研究对象,以数字单双号形式对所选病例进行划分,即对照组(n=25)、观察组(n=25)。对对照组、观察组患者分别予以89SrCl2治疗、89SrCl2与局部放射共同治疗。以VAS评分、生存质量评分和治疗疗效为判定指标,对不同治疗取得的效果情况分析。结果在比较VAS评分中,治疗后,较对照组(3.64±0.18)分,观察组(3.32±0.28)分更低,差异有统计学意义(t=4.807,P<0.05);在比较生活质量评分中,治疗后,较对照组(79.56±3.34)分,观察组(85.55±2.20)分更高,差异有统计学意义(t=7.489,P<0.05);对照组患者的治疗疗效率是68.00%,低于观察组的96.00%,差异有统计学意义(χ^(2)=4.878,P<0.05);在比较骨转移病灶数量中,较对照组的(4.37±1.04),观察组的(3.69±0.93)个更低,差异有统计学意义(t=2.437,P<0.05)。结论对多发性骨转移癌患者予以89SrCl2与局部放射共同治疗,能取得较好治疗效果,能有效改善患者病情,患者疼痛感减轻,减少骨转移病灶数量,生活质量提升。Objective To determine the object of multiple bone metastases,to explore the effect of co-treatment with strontium dichloride(89SrCl2)and local radiation.Methods From January 2017 to January 2020,50 patients with multiple bone metastases received in the hospital were randomly selected as the research objects,and the selected cases were divided in the form of digital odd and even numbers,namely the control group(n=25)and the observation group(n=25).Patients in the control group and observation group were treated with strontium dichloride,strontium dichloride and local radiation.VAS score,quality of life score and treatment efficacy were used as indicators to analyze the effects of different treatments.Results In the comparison of VAS scores,after treatment,compared with the control group's scores(3.64±0.18)points,the observation group's(3.32±0.28)points were lower,the difference was statistically significant(t=4.807,P<0.05);in the comparison of quality of life scores,after treatment,compared with the control group(79.56±3.34)points,the observation group's(85.55±2.20)points was higher,the difference was statistically significant(t=7.489,P<0.05);the treatment efficiency of the control group was 68.00%,which was lower than that of the observation group 96.00%,the difference was statistically significant(χ^(2)=4.878,P<0.05);in comparing the number of bone metastases,it was lower than the control group(4.37±1.04)and the observation group(3.69±0.93),the difference was statistically significant(t=2.437,P<0.05).Conclusion Co-treatment of patients with multiple bone metastases with strontium dichloride and local radiation can achieve better therapeutic effects,can effectively improve the patient's condition,reduce the patient's pain,reduce the number of bone metastases,and improve the quality of life.

关 键 词：多发性骨转移癌 局部放射 二氯化锶 

分 类 号：R730.5[医药卫生—肿瘤]