Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of Axially Chiral Compounds  

作　　者：Bing-Chao Da Shao-Hua Xiang Shaoyu Li Bin Tan 

机构地区：[1]Department of Chemistry and Shenzhen Grubbs Institute,Southern University of Science and Technology,Shenzhen,Guangdong 518055,China [2]Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,Guangdong 518055,China

出　　处：《Chinese Journal of Chemistry》2021年第7期1787-1796,共10页中国化学（英文版）

摘　　要：The well-defined conformational properties of axially chiral compounds bring extraordinary values to an assortment of bioactive molecules,advanced materials,organocatalysts as well as chiral ligands in asymmetric transformations.The demonstrated usefulness and untapped potential of axially chiral structural motifs stimulate increasing efforts to develop novel and efficient approaches for their preparation.In this regard,the chiral phosphoric acids broadly used in asymmetric Brønsted acid catalysis have shown high relevance for atroposelective synthesis as well.Our strong interest in reaction chemistry of atropisomers has established a rewarding research programme in our group.The course of studies will be recounted in this account,with discussion focused on the use of chiral phosphoric acids to catalyze construction of several key axially chiral structures such as BINAM,BINOL,NOBIN,arylquinones,SPINOL,arylpyrrole analogues and axially chiral alkenes.

关 键 词：Axial chirality ORGANOCATALYSIS Chiral phosphoric acid BIARYLS Asymmetric synthesis 

分 类 号：O62[理学—有机化学]