Preparation of Peptide Selenoesters from Their Corresponding Acyl Hydrazides  

作　　者：Yunxue Li Jiazhi Liu Qingqing Zhou Jie Zhao Ping Wang 

机构地区：[1]Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Chemistry and Chemical Engineering,Frontiers Science Center for Transformative Molecules,Shanghai Jiao Tong University,Shanghai,200240 China

出　　处：《Chinese Journal of Chemistry》2021年第7期1861-1866,共6页中国化学（英文版）

基　　金：Financial support for this work was gratefully received from the National Natural Science Foundation of China(Nos.22077080,21907064 and 91753102);the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2020YQ14).

摘　　要：Main observation and conclusion Selenoesters are useful substitutes for traditional thioesters in protein ligation chemistry due to their high reactivity in the trans-thio/selenoesterification reaction.However,existing synthetic routes to access peptide selenoester require a selenoesterification reaction between a selenide and a protected peptide with a free carboxylate at the C-terminus.

关 键 词：Peptides HYDRAZIDE Selenium Synthetic methods One-pot ligation 

分 类 号：O64[理学—物理化学]