Financial support for this work was gratefully received from the National Natural Science Foundation of China(Nos.22077080,21907064 and 91753102);the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2020YQ14).
Main observation and conclusion Selenoesters are useful substitutes for traditional thioesters in protein ligation chemistry due to their high reactivity in the trans-thio/selenoesterification reaction.However,existin...
This work was supported by the National Natural Science Foundation of China(Nos.21662009,21702037,31860516);the Guizhou Provincial S&T Program,China(Nos.[2017]5788,2018[1051]).
Through a facile structural modification on the natural bioactive ingredient 18β-glycyrrhetinic acid(GA),a series of novel GA hydrazide or amide derivatives was obtained,and their final molecular frameworks were char...
the National Natural Science Foundation of China(21662009,21702037,31860516,21877021);Guizhou Provincial S&T Program([2017]5788);Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[Qianjiaohe KY number(2020)004];Key Technologies R&D Program(2014BAD23B01);Program of Introducing Talents of Discipline to Universities of China(111 Program,D20023).
The present study was carried out in an attempt to synthesize a new class of antimicrobial agents containing a 1,2,3-triazole motif formed by classical copper catalyzed click chemistry.Antifungal bioassay results show...
An organogelator named N-[3-(hydroxy)-4-(dodecyloxy)-benzoyl]-N’ (4’-nitro-benzoyl) hydrazide (D12) was synthesized. It could form stable gels in some of the tested organic solvent....
the FAPESP(Fundacao de Amparo a Pesquisa de Sao Paulo)(2017/11764-2)。
New lanthanide(Eu3+ and Gd3+) complexes were successfully synthesized and the effect of the p-phe nyl substituent on the Eu3+luminescent properties was evaluated.In this sense,benzhydrazide,p-toluic hydrazide,4-hydrox...
supported by the National Key R&D Program of China(No.2017YFA0505200);the National Natural Science Foundation of China(Nos.21532004,21807001,91753205,81621002,21621003)。
The deletion of the C-terminal arginine of the anaphylatoxin protein C5a reduces it receptor binding affinity.Understanding how C-terminal arginine affects the structure and bioactivity of C5a is important for the dev...
the National Natural Science Foundation of China (Nos.91849129,21807112);PLA Youth Medical Science and Technology Youth Development Program (No.16QNP086);Foundation of Second Military Medical University (No.2016JS11)
TNFR1-associated death domain protein(TRADD)with arginine N-GlcNAcylation is a novel and structurally unique posttranslational modification(PTM)glycoprotein that blocks the formation of death-inducing signaling comple...
the grants from the National Natural Science Foundation of China (No. 31772209);the Fundamental Research Funds for the Central Universities of China (No. KYTZ201604)
A series of novel 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety were designed, synthesized and evaluated for their antifungal activities against Rhizoctonia solani (Rs), Fusarium graminearum (Fg), ...
This work was supported by the National Natural Science Foundation of China (No. 21372169) and Sichuan Provincial Foundation (2008SG0021). We acknowledge the comprehensive training platform of the specialized laboratory of the College of Chemistry, Sichuan University, for material analysis. We acknowledge the comprehensive training platform of the specialized laboratory of the College of Chemistry, Sichuan University, for material analysis. We would like to thank the Analytical & Testing Center of Sichuan University for CCD X-ray single crystal diffractometer work and circular dichroism CD spectrometer work. We are grateful to Daibing Luo and Yani Xie for help with the single crystal and circular dichroism measurements.
The simpler, the better! A series of simple and highly fluorescent salicylaldehyde hydrazide molecules (41 samples) have been designed and prepared. Even though these soft materials contain a very small π-conjugate...
supported by the Science and Technological Fund of Anhui Province for Outstanding Youth(No. 1808085J04);the Innovative Program Development Foundation Hefei Center Physical Science Technology(No. 2017FXCX002)
Nicotinic acetylcholine receptors(nAChRs) play important roles in intercellular communications of nerve cells. α-Bungarotoxins(αBtx) is a moderator for the nAChRs. Chemical synthesis provides a promising way to acce...