ANAPHYLATOXIN

作品数：3被引量：7H指数：1
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相关领域：医药卫生更多>>
相关期刊：《Science China Chemistry》《Advances in Bioscience and Biotechnology》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金更多>>
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Chemical synthesis and racemic crystallization of rat C5a-desArg被引量：1
《Chinese Chemical Letters》2020年第3期693-696,共4页Chao Zuo Baochang Zhang Meng Wu Donald Bierer Jing Shi Ge-Min Fang 
supported by the National Key R&D Program of China(No.2017YFA0505200);the National Natural Science Foundation of China(Nos.21532004,21807001,91753205,81621002,21621003)。
The deletion of the C-terminal arginine of the anaphylatoxin protein C5a reduces it receptor binding affinity.Understanding how C-terminal arginine affects the structure and bioactivity of C5a is important for the dev...
关键词：ANAPHYLATOXIN C5a RACEMIC CRYSTALLIZATION Solid phase peptide SYNTHESIS CHEMICAL protein SYNTHESIS Hydrazide-based native CHEMICAL ligation 
Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist被引量：6
《Science China Chemistry》2019年第10期1371-1378,共8页Chao Zuo Wei-Wei Shi Xiao-Xu Chen Marie Glatz Bernd Riedl Ingo Flamme Elisabeth Pook Jiawei Wang Ge-Min Fang Donald Bierer Lei Liu 
supported by the National Key R&D Program of China (2017YFA0505200);the National Natural Science Foundation of China (21532004, 91753205, 81621002, 21621003)
Blockade of the interaction of anaphylatoxin C5a with its receptor C5aR1 has been actively studied as a potential treatment for many inflammatory diseases;but current C5a antagonists exhibit inadequate potency and poo...
关键词：ANAPHYLATOXIN C5A PMX53 quasi-racemic X-ray CRYSTALLOGRAPHY native chemical LIGATION 
Synergistic interaction between C5a and NOD2 signaling in the regulation of chemokine expression in RAW 264.7 macrophages被引量：1
《Advances in Bioscience and Biotechnology》2013年第8期30-37,共8页Hui Tang Umme Amara Dora Tang Mark A. Barnes Christine McDonald Laura E. Nagy 
The innate immune response is a complex process involving multiple pathogen-recognition receptors, including toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors. Complement is...
关键词：ANAPHYLATOXIN C5L2 C5A Receptor COMPLEMENT NOD2 
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