Epoxymicranthols A-N,5,9-Epoxygrayanane Diterpenoids as Potent Analgesics from Rhododendron micranthum  

作　　者：Pengfei Jin Xinghua Yuan Xiaomin Ma Guijuan Zheng Ru Wang Na Sun Guangmin Yao 

机构地区：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430030 China

出　　处：《Chinese Journal of Chemistry》2021年第7期1997-2008,共12页中国化学（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.U1703109).

摘　　要：Main observation and conclusion Fifteen 5,9-epoxygrayanane diterpenoids(1-15)including fourteen new ones,epoxymicranthols A-N(1-14),were isolated from the leaves extract of Rhododendron micranthum.Their structures were elucidated via extensive spectroscopic methods and ^(13)C NMR-DP4+analysis,and the absolute configurations of 1,3-10,14,and 15 were confirmed by single-crystal X-ray diffraction analysis.

关 键 词：Rhododendron micranthum Turcz.(Ericaceae) Natural products Structural elucidation ANALGESICS Structure-activity relationship 

分 类 号：O62[理学—有机化学]