转录因子FOXO1在肿瘤形成中的调控作用及机制研究进展  

Research progress on the regulation and mechanism of transcription factor FOXO1 in tumorigenesis

作　　者：易陈鹏 黄锦云 许蓝阳 邹晨 黄秀媚 王启瑞[1] YI Chen-Peng;HUANG Jin-Yun;XU Lan-Yang;ZOU Chen;HUANG Xiu-Mei;WANG Qi-Rui(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学中医药学院,广州510515

出　　处：《生命科学》2021年第7期824-832,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金面上项目(81873295,82074337);广东省自然科学基金项目(2018A030313106,2019A1515012209);广东省科技创新战略专项资金(“攀登计划”专项资金,pdjh2020b0120)。

摘　　要：FOXO1(forkhead box O1)是FOXO家族重要成员,作为一种转录调控因子,其缺失可扰乱细胞增殖与死亡平衡,与肿瘤形成有着密切关系。FOXO1可通过磷酸化、乙酰化、泛素化和甲基化等多种翻译后修饰方式,与PI3K/Akt、Wnt/β-catenin等信号通路相互作用,参与调控肿瘤细胞的增殖、凋亡、EMT、氧化应激、自噬及物质代谢等多种生物学活动。该文就FOXO1相关分子通路及其在肿瘤形成中的调控作用进行综述,探讨其作为肿瘤治疗分子靶标的可能性。FOXO1(forkhead box O1),as a transcription regulator,is an important member of FOXO family.Its deficiency can break the balance between cell proliferation and death,which is intimatly related to tumorigenesis.FOXO1 can interact with PI3 K/Akt,Wnt/β-catenin or other signaling pathways through various post-translational modifications,such as phosphorylation,acetylation,ubiquitination and methylation,to participate in the regulation of proliferation,apoptosis,EMT,oxidative stress,autophagy and metabolism of tumor cells.In this review,FOXO1-related molecular pathways and its role in tumorigenesis are described,and the prospect of FOXO1 as a candidate molecular target for tumor therapy is discussed.

关 键 词：FOXO1 翻译后修饰 生物学功能 信号通路 肿瘤形成 

分 类 号：R730.23[医药卫生—肿瘤]