白细胞介素18在癌症中的研究进展  

Research Progress of Interleukin-18 in Cancer

作　　者：郭磊 辛本凯 沈若琪 张纪周[1] 肖业臣[1,3] Guo Lei;Xin Benkai;Shen Ruoqi;Zhang Jizhou;Xiao Yechen(Department of Biochemistry,College of Basic Medical Sciences,Jilin University,Changchun 130021;School of Public Health,Jilin University,Changchun 130021;Department of Biotechnology,College of Basic Medical Sciences,Guangdong Medical University,Dongguan 523000)

机构地区：[1]吉林大学基础医学院生物化学教研室,长春130021 [2]吉林大学公共卫生学院,长春130021 [3]广东医科大学基础医学院生物技术系,东莞523000

出　　处：《国际老年医学杂志》2021年第5期305-308,共4页International Journal of Geriatrics

基　　金：吉林省重点科技研发项目(20180201030YY)。

摘　　要：白细胞介素18(IL-18)是IL-1家族具有诱导干扰素-γ(IFN-γ)功能的促炎细胞因子,具有增强自然杀伤(NK)细胞的细胞毒性、促进T细胞增殖的作用。IL-18与IL-12协同作用可促进Th1细胞分化,与IL-2结合可以刺激细胞毒性T细胞、NK细胞产生IFN-γ,发挥抑癌或致癌的双重作用。在癌症的治疗过程中,IL-18与免疫检查点抑制剂联合使用,能够有效抑制癌症的发展。本文对IL-18的生物学活性,在癌症发生、发展过程中的两面性及免疫治疗中的作用做一综述。Interleukin-18(IL-18)is a proinflammatory cytokine of interleukin-1(IL-1)family with the function of inducing interferon-γ(IFN-γ),which enhances the cytotoxicity of natural killer(NK)cells and promotes the proliferation of T cells.The synergistic effect of IL-18 and IL-12 promotes the differentiation of Th1 cells,and the combination with interleukin-2(IL-2)can stimulate the production of IFN-γby cytotoxic T cells and NK cells,thus playing a dual role of tumor suppressor or carcinogenesis.In the treatment of cancer,IL-18 is used in combination with immune checkpoint inhibitors,which effectively inhibits the development of cancer.This article reviews the biological activity of IL-18,its dual role in the occurrence and development of cancer and its role in immunotherapy.

关 键 词：白细胞介素18 生物活性 癌症 免疫治疗 

分 类 号：R730.3[医药卫生—肿瘤]