Isotretinoin for the treatment of nonobstructive azoospermia: a pilot study  

作　　者：John K Amory Charles H Muller Thomas J Walsh 

机构地区：[1]Department of Medicine,University of Washington,Seattle,WA 98195,USA [2]Department of Urology,University of Washington,Seattle,WA 98195,USA

出　　处：《Asian Journal of Andrology》2021年第5期537-540,共4页亚洲男性学杂志（英文版）

基　　金：The Eunice Kennedy Shriver National Institute of Child Health and Human Development supported this work through grant K24HD082231 to John K Amory.

摘　　要：The treatment of men with infertility from azoospermia is challenging.As some men with severe oligozoospermia improve sperm output during treatment with isotretinoin,we treated nine men with azoospermia with isotretinoin to determine if azoospermic men would also respond to isotretinoin treatment.One of these men who had a previous negative testicular sperm extraction(TESE)was found to have an area of sperm production on a postisotretinoin testicular extraction.This man achieved a pregnancy and a live birth of a healthy,term daughter after in vitro fertilization coupled with intracytoplasmic sperm injection(IVF/ICSI).A second subject had a positive TESE after treatment as well.Additional study of isotretinoin therapy in men with azoospermia undergoing testicular sperm harvesting procedures is warranted.

关 键 词：TREATMENT INJECTION PREGNANCY 

分 类 号：R697[医药卫生—泌尿科学]