蛋白质组学在缺血性中风的研究进展  

Research Progress of Proteomics in Ischemic Stroke

作　　者：黄泽 胡跃强[2] 陈莲梅 吴晓清 钟云薇 HUANG Ze;HU Yueqiang;CHEN Lianmei;WU Xiaoqing;ZHONG Yunwei(Guangxi University of Chinese Medicine,Nanning 530022,Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China)

机构地区：[1]广西中医药大学,广西南宁530022 [2]广西中医药大学第一附属医院,广西南宁530023

出　　处：《中华中医药学刊》2021年第8期166-170,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81860842);广西科技厅重点研发计划(桂科AB18221020);广西中医药大学岐黄工程高层次人才团队培育项目(2018003);广西中医药大学第一附属医院学术团队项目(院字2018[146])。

摘　　要：近年来对缺血性中风的研究越发深入,其中蛋白质组学在缺血性中风的研究取得了一定的进展。而中医药因其独特的优势,在缺血性中风的防治方面疗效满意。蛋白质组学能从分子、细胞和组织层面探究缺血性中风的发病机理,以及利用血液、脑脊液和尿液等筛选特定生物标志物以早期识别缺血性中风,同时能评估药物的作用和疗效,寻找中医药的起效机制。但是,现有研究成果和结论仍待大样本的实验研究证实。蛋白质组学在神经系统疾病防治方面将扮演着重要角色,就蛋白质组学在缺血性中风的机制、诊断和治疗方面的研究,以及中医药的起效作用研究进展进行综述。In recent years, the study of ischemic stroke has become more and more in-depth, in which proteomics has made some progress in the study of ischemic stroke. Because of its unique advantages, traditional Chinese medicine has a satisfactory effect in the prevention and treatment of ischemic stroke. Proteomics can explore the pathogenesis of ischemic stroke from the molecular, cellular and tissue levels, and use blood, cerebrospinal fluid and urine to screen specific biomarkers to identify ischemic stroke in the early stage. And at the same time, the effect and efficacy of drugs can be evaluated, looking for the effective mechanism of traditional Chinese medicine. However, the existing research results and conclusions still need to be confirmed by large sample experimental studies. Proteomics plays an important role in the prevention and treatment of nervous system diseases. This article reviewed the research progress of proteomics in the mechanism, diagnosis and treatment of ischemic stroke, as well as the effect of traditional Chinese medicine.

关 键 词：蛋白质组学 缺血性中风 中医药 研究进展 

分 类 号：R743.3[医药卫生—神经病学与精神病学]