HER2、G-17与胃蛋白酶原C在胃癌中的表达及临床意义  

Expression and clinical significance of HER2,G-17 and pepsinogen C in gastric cancer

作　　者：李洪 冯雪晶 秦维 庄恢勇 LI Hong;FENG Xuejing;QIN Wei;ZHUANG Huiyong(Department of Clinical Laboratory,Qionghai People′s Hospital,Qionghai,Hainan 222000,China)

机构地区：[1]琼海市人民医院检验科,海南琼海222000

出　　处：《国际检验医学杂志》2021年第18期2200-2203,共4页International Journal of Laboratory Medicine

基　　金：海南省医药卫生科研项目(1904320116A2001)。

摘　　要：目的探讨表皮生长因子受体2(HER2)、胃泌素-17(G-17)及胃蛋白酶原C在胃癌中的表达及临床意义。方法利用免疫组织化学法检测胃癌组、癌旁组及正常胃黏膜组HER2、G-17及胃蛋白酶原C阳性表达率,并对不同临床病理特征间HER2、G-17、胃蛋白酶原C表达率进行比较分析。结果正常胃黏膜组、癌旁组及胃癌组HER2、G-17及胃蛋白酶原C阳性表达率比较,差异有统计学意义(P<0.05)。胃癌组不同Lauren分型、分化程度、淋巴转移患者间HER2阳性表达率比较,差异有统计学意义(P<0.05)。胃癌组不同分化程度、淋巴转移、TNM分期患者间G-17阳性表达率比较,差异有统计学意义(P<0.05)。胃癌组不同分化程度、淋巴转移、TNM分期患者间胃蛋白酶原C阳性表达率比较,差异有统计学意义(P<0.05)。结论胃癌患者HER2、G-17及胃蛋白酶原C阳性表达率可作为胃癌筛查指标,为胃癌的早诊断、早治疗提供可靠的临床依据。Objective To investigate the expression of epidermal growth factor receptor 2(HER2),gastrin-17(G-17)and pepsinogen C in gastric cancer and its clinical significance.Methods Immunohistochemistry was used to detect the positive expression rates of HER2,G-17 and pepsinogen C in gastric cancer group,para-carcinoma group and normal gastric mucosa group,and the expression rates of HER2,G-17 and pepsinogen C among different clinicopathologic features were compared and analyzed.Results The positive expression rates of HER2,G-17 and pepsinogen C in normal gastric mucosa group,para-carcinoma group and gastric cancer group were significantly different(P<0.05).There were statistically significant differences in HER2 positive expression rates among patients with different Lauren types,differentiation degree and lymph node metastasis in gastric cancer group(P<0.05).The positive expression rate of G-17 among patients with different differentiation degree,lymph node metastasis and TNM stage in gastric cancer group was statistically significant(P<0.05).There was statistical significance in the positive expression rate of pepsinogen C among patients with different differentiation degree,lymph node metastasis and TNM stage in gastric cancer group(P<0.05).Conclusion The positive expression rates of HER2,G-17 and pepsinogen C in patients with gastric cancer can be used as screening indicators for gastric cancer,which provides a reliable clinical basis for early diagnosis and treatment of gastric cancer.

关 键 词：胃癌 表皮生长因子受体2 胃泌素-17 胃蛋白酶原C 

分 类 号：R735.2[医药卫生—肿瘤]