非酒精性脂肪性肝病患者乙醛脱氢酶2基因多态性变化观察  

Changes of ALDH2 gene polymorphisms in patients with nonalcoholic fatty liver disease

作　　者：柯月[1] 张杰[2] 梁灿灿[1] 纪文静[1] KE Yue;ZHANG Jie;LIANG Cancan;JI Wenjing(The Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学第二附属医院,乌鲁木齐830000 [2]新疆维吾尔自治区人民医院

出　　处：《山东医药》2021年第15期32-35,共4页Shandong Medical Journal

基　　金：新疆维吾尔自治区自然科学基金资助项目(2019D01C237)。

摘　　要：目的观察非酒精性脂肪性肝病(NAFLD)患者乙醛脱氢酶2(ALDH2)基因多态性的变化,并分析ALDH2基因多态性与NAFLD发生的关系。方法 120例NAFLD患者(NAFLD组),汉族60例、维吾尔族60例,选取同期健康体检者60例(对照组),汉族30例、维吾尔族30例。采用DNA芯片高通量测序检测两组受试对象基因多态性。收集患者血糖、糖化血红蛋白、血脂、尿酸、肝功能等NAFLD传统影响因素指标。采用Logistic回归模型分析乙醛脱氢酶2基因多态性与NAFLD患者发生及其传统危险因素的关系。结果 NAFLD组和对照组ALDH2基因GA/AA型比例分别为50.8%和30.0%,两组比较,P<0.05;NAFLD患者中汉族人群中ALDH2基因GA/AA型比例高于维吾尔族人群(P<0.05)。Logistic回归分析显示,GA/AA型者NAFLD患病风险升高5.984倍,其体质量、空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇、尿酸高于GG型者(P均<0.05);调整其他NAFLD危险因素后,ALDH2基因多态性与NAFLD相关(P<0.01),但NAFLD患者ALDH2基因不同表型与纳入的传统危险因素之间无关(P均>0.05)。结论 NAFLD患者ALDH2基因GA/AA型比例升高,NAFLD患者中汉族人群ALDH2基因GA/AA型的比例高于维吾尔族人群,ALDH2基因多态性与NAFLD的发生有关。Objective tients with nonalcoholic fatty liver disease(NAFLD)and their relationship with the occurrence of NAFLD.Methods tally 120 cases of NAFLD patients(NAFLD group)including 60 cases of Han nationality and 60 cases of Uygur nationality,and 60 cases of healthy people(control group)including 30 cases of Han nationality and 30 cases of Uygur nationality,were selected. High throughput DNA chip sequencing was used to detect the gene polymorphisms of the two groups. Liver stiffness,controlled attenuation parameter(CAP),blood glucose,glycosylated hemoglobin,blood lipid,uric acid and other biochemical indexes were measured by transient elastography. The correlation between ALDH2 gene polymorphism and the occurrence of NAFLD,and the risk factors for NAFLD patients were analyzed by Logistic regression model.Results er group(P<0. 05);the proportion of GA/AA genotype in the fatty liver of Han population was higher than that in the Uygur population,and the difference was statistically significant(P<0. 05). Logistic regression analysis showed that the risk of NAFLD in GA/AA type was 5. 984 times higher than that in GG type(P<0. 05). After adjusting other risk factors of fatty liver,ALDH2 gene polymorphism was related to NAFLD(P<0. 01). There was no significant correlation between different phenotypes and the risk factors(all P>0. 05).Conclusion is high in NAFLD patients. The percentage of GA/AA genotype in the ALDH2 gene in Han population is higher than that in Uygur population. ALDH2 gene polymorphism is associated with NAFLD.

关 键 词：乙醛脱氢酶2 基因多态性 非酒精性脂肪性肝病 

分 类 号：R575.[医药卫生—消化系统]