涎腺癌分子病理研究及临床应用进展  

Research progress in molecular pathology of salivary gland carcinoma and clinical application

作　　者：张晓阳[1] 杨春蕊 董化江[2] Zhang Xiaoyang;Yang Chunrui;Dong Huajiang(Department of Pathology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China;Logistics University of Chinese People's Armed Police Forces,Tianjin 300189,China)

机构地区：[1]天津医科大学第二医院病理科,300211 [2]中国人民武装警察部队后勤学院,天津300189

出　　处：《国际生物医学工程杂志》2021年第3期250-255,共6页International Journal of Biomedical Engineering

基　　金：天津医科大学第二医院青年科研基金(2020ydey06);国家自然科学基金(81801240)。

摘　　要：涎腺癌是一组异质性恶性肿瘤。世界卫生组织(2017)头颈部肿瘤分类将涎腺癌分为22种组织病理学亚型,临床最常见亚型包括黏液表皮样癌、腺样囊性癌、涎腺导管癌、腺泡细胞癌和分泌性癌等。涎腺癌各亚型组织形态学重叠,诊断和鉴别诊断困难。涎腺癌的主要治疗方式是手术切除,酌情术后放射治疗。对于局部进展、复发和转移性病例,治疗方式有限,主要还是姑息性治疗。肿瘤受体表达、基因组和通路改变等的精准确定是改善局部进展或远处转移患者预后的关键。概述了常见涎腺癌组织学亚型的遗传突变、扩增和蛋白表达谱等分子遗传学改变及其对疾病诊断、未来研究和个性化靶向治疗的意义。Salivary gland cancer includes a group of heterogeneous malignant tumors.The latest WHO classification of head and neck tumors divides salivary gland cancer into 22 histopathological subtypes.The most common clinical subtypes include mucoepidermoid carcinoma,adenoid cystic carcinoma,salivary duct carcinoma,acinar cell carcinoma and secretory carcinoma,etc.The histomorphology of the subtypes of salivary gland cancer overlaps,making diagnosis and differential diagnosis difficult.The main treatment for salivary gland cancer is tumor resection and postoperative radiotherapy as appropriate.Even in cases of local progression,recurrence and metastasis,the treatment options available are limited,mainly palliative treatment.Accurate determination of tumor receptor expression,genome and pathway changes is the key to changing the prognosis of patients with local progression or distant metastasis.In this paper,the known genetic mutations,amplifications and protein expression profiles of common salivary gland cancer histological subtypes was summarized,and the significance of the above-mentioned molecular genetic changes for disease diagnosis,future research and personalized targeted therapy was analyzed.

关 键 词：涎腺肿瘤 病理学 分子 靶向治疗 

分 类 号：R739.87[医药卫生—肿瘤]