颅内未破裂动脉瘤的炎性反应机制及高分辨率磁共振成像评估和潜在治疗药物的研究进展  

Research progress of inflammatory reaction mechanism and evaluation of high-resolution magnetic resonance and potential therapeutic drugs of unruptured intracranial aneurysms

作　　者：秦锦标 朱敏 刘高飞 Qin Jinbiao;Zhu Min;Liu Gaofei(Department of Neurology,Qinhuai Medical District,Eastern Theater General Hospital,Nanjing 210002,China)

机构地区：[1]东部战区总医院秦淮医疗区神经内科,南京210002

出　　处：《中国脑血管病杂志》2021年第9期628-633,共6页Chinese Journal of Cerebrovascular Diseases

摘　　要：颅内未破裂动脉瘤具有患病率高、破裂率高、破裂后致残致死率高等特点。探讨其形成和破裂的机制成为目前研究的热点。研究表明,炎性反应介导的血管壁病理性重塑是颅内未破裂动脉瘤形成和破裂的重要机制。作者对颅内未破裂动脉瘤形成和破裂的炎性反应机制、高分辨率磁共振的评估、潜在治疗药物进行了综述。Unruptured intracranial aneurysms had characteristics of high incidence rate,high rupture rate and high rate of disability and mortality after rupture.Exploring the mechanism of its formation and rupture has been the main focus of current researches.Previous researches showed that pathological remodeling of vascular wall mediated by inflammatory reaction is an important mechanism for the formation and rupture of unruptured intracranial aneurysms.The authors reviewed inflammatory response mechanism of the formation and rupture of unruptured intracranial aneurysms,evaluation of high-resolution magnetic resonance,and potential therapeutic drugs.

关 键 词：颅内动脉瘤 未破裂动脉瘤 炎性反应 高分辨率磁共振 治疗药物 综述 

分 类 号：R743[医药卫生—神经病学与精神病学]