Attributable deaths of liver cancer in China  

作　　者：Maomao Cao Chao Ding Changfa Xia He Li Dianqin Sun Siyi He Wanqing Chen 

机构地区：[1]Office of Cancer Screening,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement,Beijing 100021,China [2]Department of Anesthesiology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China

出　　处：《Chinese Journal of Cancer Research》2021年第4期480-489,共10页中国癌症研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81974492);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2019PT320027);Sanming Project of Medicine in Shenzhen(No.SZSM201911015)。

摘　　要：Objective:There is little information about contributions of the well-known risk factors to the liver cancer burden.We conducted a comparative study to estimate the liver cancer burden attributable to major risk factors.Methods:Liver cancer deaths for adults were estimated from 978 county-level surveillance points in China in2014.Risk factors were identified from the International Agency for Research on Cancer and the World Cancer Research Fund International.Population attributable fraction(PAF)by age,sex,and province was calculated using multiple formulas.Results:In total,72.4%of liver cancer deaths could be attributable to the studied risk factors.Hepatitis B virus(HBV)was responsible for the largest fraction of liver cancer burden in both genders(PAF=55.6%in males,PAF=46.5%in females).PAFs for liver cancer burden attributable to smoking(15.7%vs.4.8%),and alcohol drinking(10.3%vs.1.6%)were significantly higher in males than in females.The burden of HBV-attributable deaths was the highest in Qinghai province.Conclusions:HBV still contributes to the majority of liver cancer burden than any other risk factors.Targeted preventive measures should be implemented based on the degree of contributions of risk factors to liver cancer deaths.

关 键 词：Liver cancer population attributable fraction comparative study China 

分 类 号：R735.7[医药卫生—肿瘤]