乳腺癌磁共振动态增强扫描影像组学特征与生物学预后因子的关系  

Correlation between DCE-MRI imaging features and biological prognostic factors in breast cancer with dynamic contrast-enhanced MRI

作　　者：宋园园 韩晓凤 白娜娜 SONG Yuanyuan;HAN Xiaofeng;BAI Na’na(Imaging Center,the First Affiliated Hospital of He’nan University of Science and Technology,Luoyang 471003,He’nan,China)

机构地区：[1]河南科技大学第一附属医院影像中心,河南洛阳4710030

出　　处：《癌症进展》2021年第15期1568-1572,1601,共6页Oncology Progress

摘　　要：目的探讨乳腺癌磁共振动态增强扫描(DCE-MRI)影像组学特征与生物学预后因子的关系。方法选取100例乳腺癌患者,所有患者在术前均接受磁共振(MRI)平扫和增强扫描,术中收集患者肿瘤组织,术后采用免疫组织化学染色法检测肿瘤组织中增殖细胞核抗原(Ki-67)、人类表皮生长因子受体2(HER2)、缺氧诱导因子-2α(HIF-2α)阳性表达率。分析DCE-MRI影像组学特征中肿瘤形态、边缘、内部强化、时间-信号强度曲线(TIC)分型与乳腺癌组织分级、淋巴结转移、Ki-67、HER2、HIF-2α表达的关系,并比较Ki-67、HER2、HIF-2α阳性、阴性表达的乳腺癌患者3年生存情况。结果有分叶者淋巴结转移比例高于无分叶者(P﹤0.05),环形强化者低分化、淋巴结转移比例均高于其他强化方式(P﹤0.05);有分叶者Ki-67阳性率、HIF-2α阳性率均高于无分叶者(P﹤0.05),不均匀强化者HIF-2α阳性率高于其他强化方式(P﹤0.05),TIC分型Ⅱ型者Ki-67阳性率高于其他型(P﹤0.05);有分叶者出现Ki-67、HIF-2α阳性的概率分别是无分叶者的4.759、3.951倍(P﹤0.05);环形强化是肿瘤内部强化中出现HIF-2α阳性的保护因素(P﹤0.05);Ki-67、HER2、HIF-2α蛋白表达呈阳性的乳腺癌患者3年生存率均低于阴性患者(P﹤0.05)。结论乳腺癌患者DCE-MRI影像组学特征与其生物学预后因子Ki-67、HIF-2α存在一定的关系,可间接反映乳腺癌患者的预后情况。Objective To investigate the relationship between the imaging features and biological prognostic factors in breast cancer with dynamic enhanced magnetic resonance imaging(DCE-MRI).Method A total of 100 patients with breast cancer were selected.All patients received plain MRI and enhanced MRI before surgery,and tumor tissues were collected during surgery.Immunohistochemistry was used to detect the positive expression rates of proliferating cell nu-clear antigen(Ki-67),human epidermal growth factor receptor-2(HER2)and hypoxia inducible factor-2α(HIF-2α)in tu-mor tissues.The correlation of tumor morphology,edge,internal enhancement,time-signal intensity curve(TIC)type with tissue grade,lymph node metastasis,Ki 67,HER2,HIF 2αexpression in breast cancer with DCE-MRI image were compared.The 3-year survival of breast cancer patients with positive and negative expression of Ki-67,HER2 and HIF-2αwere analyzed.Result The proportion of lymph node metastasis in lobulated patients was higher than that in non-lobulated patients(P<0.05),and the proportion of low differentiation and lymph node metastasis in ring enhancement patients were higher than those in uniform and uneven enhancement patients(P<0.05).The positive rates of Ki-67 and HIF-2αin patients with lobulation were higher than those without lobulation(P<0.05),the positive rates of HIF-2αin pa-tients with uneven enhancement were higher than those with other intensities(P<0.05),and the positive rates of Ki-67 in patients with TIC curve type II were higher than those with other intensities(P<0.05).The positive probabilities of Ki 67 and HIF-2αwere 4.759 and 3.951 times higher in patients with lobulation than those without lobulation(P<0.05).Ring enhancement was a protective factor for HIF-2αpositive(P<0.05).The 3-year survival rate of breast cancer pa-tients with positive expression of Ki-67,HER2 and HIF-2αwas lower than those of negative breast cancer patients(P<0.05).Conclusion There is a certain correlation between DCE-MRI imaging features and biological progn

关 键 词：磁共振动态增强扫描 乳腺癌 生物学预后因子 增殖细胞核抗原 人类表皮生长因子受体2 缺氧诱导因子-2Α 

分 类 号：R737.9[医药卫生—肿瘤]