术前血清miRNA-3120-5p水平对结肠癌根治术患者复发转移的预测价值分析  

Preoperative serum miRNA-3120-5p in predicting recurrence and metastasis of patients undergoing radical resection of colon cancer

作　　者：万品文[1] 万春[1] WAN Pinwen;WAN Chun(Department of Liver Surgery,Nanyang Central Hospital,Nanyang 473000,He’nan,China)

机构地区：[1]南阳市中心医院肝脏外科,河南南阳4730000

出　　处：《癌症进展》2021年第15期1589-1592,共4页Oncology Progress

摘　　要：目的探讨术前血清miRNA-3120-5p水平对结肠癌根治术患者复发转移的预测价值。方法将109例接受结肠癌根治术的原发性结肠癌患者作为结肠癌组,取100名同期进行体检的健康志愿者作为正常对照组。对比结肠癌组、正常对照组血清miRNA-3120-5p水平的差异,分析术前miRNA-3120-5p水平对结肠癌根治术患者复发转移的预测价值及结肠癌根治术患者复发转移的危险因素。结果结肠癌组患者术前血清miRNA-3120-5p水平高于正常对照组,差异有统计学意义(P﹤0.05)。术前血清miRNA-3120-5p水平预测结肠癌根治术患者复发转移的最佳截断值为0.68,曲线下面积(AUC)为0.816(95%CI:0.730~0.902),对应的灵敏度、特异度分别为69.33%、70.59%。TNM分期较高、分化程度较低、合并淋巴结转移、术前癌胚抗原(CEA)水平增高、术前血清miRNA-3120-5p水平较高是结肠癌根治术患者复发转移的独立危险因素(P﹤0.05)。结论结肠癌患者术前血清miRNA-3120-5p水平异常增高,对结肠癌根治术患者复发转移具有早期预测价值,且是导致术后复发转移的独立危险因素之一。Objective To investigate the value of preoperative serum miRNA-3120-5p in predicting recurrence and metastasis of patients undergoing radical resection of colon cancer.Method A total of 109 cases of primary colon cancer patients undergoing radical resection surgery were selected into the colon cancer group.During the same period,100 cas-es of healthy volunteers undergoing physical examination were selected into the control group.The difference of serum miRNA-3120-5p level between the two groups was compared,predictive value of preoperative miRNA-3120-5p level for recurrence and metastasis in colon cancer patients undergoing radical resection was analyzed,and the risk factors for post-operative recurrence and metastasis of colon cancer were analyzed.Result Preoperative serum miRNA-3120-5p level in colon cancer group was higher than that in control group(P<0.05).Optimal cut-off value of preoperative serum miRNA 3120-5p level for predicting postoperative recurrence and metastasis was 0.68,area under the curve(AUC)was 0.816(95%CI:0.730-0.902),the corresponding sensitivity and specificity were 69.33% and 70.59%,respectively.Higher TNM stage,lower differentiation degree,concomitant lymph node metastasis,increased preoperative carcinoembryonic antigen(CEA)level,higher preoperative serum miRNA-3120-5p level were independent risk factors for recurrence and metasta-sis of colon cancer patients after radical resection(P<0.05).Conclusion Abnormal increase of preoperative serum miR-NA3120-5p in colon cancer patients has early predictive value for recurrence and metastasis,which is one of indepen-dent risk factors for recurrence and metastasis after radical surgery.

关 键 词：结肠癌根治术 miRNA-3120-5p 复发转移 预测 

分 类 号：R735.35[医药卫生—肿瘤]